ArticleInternational journal of clinical and experimental medicine2015
Using foci number to predict central lymph node metastases of papillary thyroid microcarcinomas with multifocality.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Hashimoto's thyroiditis reduces central lymph node metastasis risk in papillary thyroid microcarcinoma: an integrated meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The incidence and risk factors for central lymph node metastasis in cN0 papillary thyroid microcarcinoma: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Associations between BRAF(V600E) and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis.World journal of surgical oncology · 2016Pooled it
- Article
- The Impact of Total Tumor Diameter on Lymph Node Metastasis and Tumor Recurrence in Papillary Thyroid Carcinomas.Diagnostics (Basel, Switzerland) · 2024Article
- Prognostic factors for incomplete response in thyroid microcarcinoma: an analysis of initial response to therapy in 517 patients.Archives of endocrinology and metabolism · 2021Article
- Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma.World journal of clinical cases · 2020Review
- Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database.Endocrine connections · 2019Article
- Active surveillance for young patients with insular thyroid cancer: an initial and novel finding.American journal of translational research · 2019Article
- Retrospective analysis of prognostic factors in patients of papillary thyroid microcarcinoma.Oncotarget · 2018Article
- Multifocality is associated with central neck lymph node metastases in papillary thyroid microcarcinoma.Cancer management and research · 2018Article
- Influence of tumor extent on central lymph node metastasis in solitary papillary thyroid microcarcinomas: a retrospective study of 1092 patients.World journal of surgical oncology · 2017Article
- Relationships between clinicopathological prognostic factors in papillary thyroid microcarcinoma: a refined analysis based on 428 cases.International journal of clinical and experimental pathology · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of our study is to analyze the clinicopathological characteristics and treatment options for papillary thyroid microcarcinomas with multifocality and investigated whether the number of foci in papillary thyroid microcarcinomas with multifocality can predict central lymph node metastases. Methods Records of 329 consecutive PTMC patients with multifocality, and who were treated surgically between 2003 and 2014 were reviewed. Patients with multifocality were identified by histopathology. The number of foci, size of the largest tumour, presence of extrathyroidal invasion, infiltration, and other clinicopathological parameters were collected and analyzed for all the cases.
resultsUnivariate analysis, age, sex, maximum tumour size, and extrathyroidal invasion were found to be significant prognostic factors (P = 0.001, 0.020, < 0.001, 0.043; respectively). Multivariate analysis found that age, sex, and maximum tumour size were independent prognostic factors for CLNM in PTMCs. Among them, Male patients (odds ratio 1.887; 95% confidence interval [CI] 1.053-3.380) and with maximum tumour size > 0.5 cm (odds ratio 2.819; 95% CI 1.721-4.616) were risk factors for increased incidence of CLNM. Patients ≥ 45 years (odds ratio 0. 497; 95% CI 0.309-0.800) were less likely to present with CLNM. However, extrathyroid invasion was not an independent predictor of CLNM according to our results. PTMCs with 2, 3, ≥ 4 foci had a significantly greater risk of CLNM (odds ratio 1.675, 2.360, 2.703; 95% CI 1.195-2.347, 1.425-3.906, 1.411-5.178; respectively) compared to PTMCs with unifocality.
conclusionsFoci numbers were linked to an increased incidence of central lymph node metastases in papillary thyroid microcarcinomas with multifocality, and we could choose to perform more radical treatment in patients with multifocality.
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