The association and interaction analysis of metabolic syndrome and chronic kidney disease on cardiovascular autonomic neuropathy in the general Chinese population.

Jin Zhang, Nai-Jia Liu, Yan Zhang, Hong Yang, Zachary Tang

Abstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.4field-weighted citation impact, top 34% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

The Cohort Study on Prediction of Incidence of All-Cause Mortality by Metabolic Syndrome.PloS one · 2016
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jin ZhangDepartment of Nephrology, The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou, China.

Nai-Jia LiuDepartment of Endocrinology, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai, China.

Yan ZhangDepartment of Nephrology, The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou, China.

Hong YangDepartment of Nephrology, The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou, China.

Zachary TangDepartment of Endocrinology, Shanghai Tongji Hospital, Tongji University School of Medicine Shanghai, China.

Fifth Affiliated Hospital of Zhengzhou University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to evaluate associations of metabolic syndrome (MetS) and chronic kidney disease (CKD) with cardiovascular autonomic neuropathy (CAN), and to estimate the extent to which interaction of MetS and CKD affects the outcome in the Chinese population.

methodWe conducted a large-scale, population-based study to analyze the association and interaction of the two factors for CAN in a sample of 2,092 Chinese people. Univariate and multiple linear regression (MLR) analysis were employed to detect these relationships. Interaction on an additive scale can be calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S).

resultsMLR adjusted for confounding factors showed that MetS was independently associated with CAN (P < 0.001). A significant interaction effect was detected by MLR (P = 0.042). In addition, a positive interaction between MetS and CKD on CAN was estimated by using parameters of RETI = 0.119 (95% CI: 0.059-0.178), AP = 0.049 (95% CI: -0.039-0.138) and S = 1.091 (95% CI: 0.164-2.019).

conclusionOur findings suggest that MetS is independently associated with CAN and offer evidence to support the hypothesis that MetS and CKD have positive interactions on CAN.

Indexed as

cardiovascular autonomic neuropathychronic kidney diseaseinteraction analysisMetabolic syndrome

Identifiers

PMID26309639

PMCPMC4538176

OpenAlexW1173539388

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.