ArticleInternational journal of clinical and experimental medicine2015
Potential role for carbon nanoparticles identification and preservation in situ of parathyroid glands during total thyroidectomy and central compartment node dissection.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Pooled it
- Parathyroid autotransplantation into the brachioradialis protects parathyroid function during total thyroidectomy.Frontiers in endocrinology · 2026Trial
- Trial
- Article
- Nanoparticles for Lymph Node-Directed Delivery.Pharmaceutics · 2023Review
- Review
- The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview.Molecules (Basel, Switzerland) · 2022Review
- The utility of indocyanine green (ICG) for the identification and assessment of viability of the parathyroid glands during thyroidectomy.Updates in surgery · 2022Observational
- The advantages of carbon nanoparticles in level VII lymph node dissection in patients with papillary thyroid cancer.Gland surgery · 2021Article
- Carbon nanoparticles suspension injection for photothermal therapy of xenografted human thyroid carcinomaMedComm · 2020Article
- Do carbon nanoparticles really improve thyroid cancer surgery? A retrospective analysis of real-world data.World journal of surgical oncology · 2020Article
- Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas.Molecules (Basel, Switzerland) · 2020Review
- Fine-needle aspiration with rapid parathyroid hormone assay to identify parathyroid gland in thyroidectomy.Medicine · 2020Article
- Reduction in postoperative hypoparathyroidism following carbon nanoparticle suspension injection combined with parathyroid gland vasculature preservation.The Journal of international medical research · 2020Article
- Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review).Sovremennye tekhnologii v meditsine · 2020Review
- Effects of Supplemental Perioperative Oxygen in Preventing Transient Hypoparathyroidism After Total Thyroidectomy.Cureus · 2018Article
- Short and Long-Term Potential Role of Carbon Nanoparticles in Total Thyroidectomy with Central Lymph Node Dissection.Scientific reports · 2018Article
- Bioaccumulation and Toxicity of Carbon Nanoparticles Suspension Injection in Intravenously Exposed Mice.International journal of molecular sciences · 2017Article
- Observational
- Increased identification of parathyroid glands using near infrared light during thyroid and parathyroid surgery.Surgical endoscopy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the potential role of intraoperative carbon nanoparticles (CN) injections for identification and preservation of parathyroid glands, thereby reducing the postoperative hypocalcaemia.
methods100 patients with thyroid cancer who underwent total thyroidectomy and central compartment node dissection (CCND) were randomly assigned to receive intraoperative injection of (CN) or not for identifying and preserving normal parathyroid glands.
resultsThere was no significantly difference for preoperative and postoperative parathyroid hormone (PTH) levels between the CN and control group (P>0.05). The levels of albumin-adjusted serum calcium (AASC) before surgery and at day 1 and 1 month after surgery did not reach the significant difference between the two groups (P>0.05). However, the patients in CN group had the higher level of AASC at day 3 after surgery than those in control group (P=0.044). Transient postoperative hypoparathyroidism occurred in 24 (48%) patients in CN group and 28 (56%) in control groups, respectively (P=0.423). The incidence of transient postoperative hypocalcemia was 20% (10/50) in CN group and 24% (12/50) in control groups, respectively (P=0.629).
conclusionsCarbon nanoparticles can make the thyroid gland and the central lymph node black-stained, but no-stained for parathyroid glands. After rapidly identifying parathyroid and distinguishing it from thyroid and lymph nodes by carbon nanoparticles, complete lymph node dissection and preservation of parathyroid glands become feasible during total thyroidectomy with neck lymph node dissection. After identification, strict adherence to capsular dissection remains essential for safe preservation in situ of the parathyroid glands and their blood supply.
Indexed as
Identifiers
26309638PMC4538139W2415590014What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.