ArticleInternational journal of clinical and experimental medicine2015
Lipoprotein lipase gene Hind III polymorphism was associated with hemorrhagic stroke.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- The HindIII and PvuII polymorphisms of lipoprotein lipase (LPL) gene reduce the risk of ischemic stroke (IS): A meta-analysis.Medicine · 2018Pooled it
- Association of HindIII Polymorphism of the Lipoprotein Lipase (LPL) Gene (rs320) and Plasma Metabolic Parameters in a Nigerian Population.Biochemical genetics · 2026Article
- Lipoprotein Lipase/Apolipoprotein Cll Gene Polymorphism in Kurdish Patients With Severe Hypertriglyceridemia.Cureus · 2023Article
- Genetics, Dyslipidemia, and Cardiovascular Disease: New Insights.Current cardiology reports · 2019Review
- Lipoprotein lipase gene polymorphisms as risk factors for stroke: a computational and meta-analysis.Iranian journal of basic medical sciences · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relevance between lipoprotein lipase (LPL) Hind III gene polymorphism and cerebral hemorrhage.
methodsA case-control study was performed utilizing PCR-RFLP method and sequencing of amplified products to detect LPL Hind III gene polymorphism in 350 cases of hemorrhagic stroke (HS group) and 350 healthy subjects (control group). Blood lipids and glucose levels were also recorded for each attendant.
resultsIn HS group, T and G allele frequencies were 90.8% and 9.2%, respectively; while those in the control group were 82.3% and 17.7%. In HS group, detection rate of the G allele frequency and GG genotype were significantly lower than those in the control group. In addition, TG, LDL-C, fasting blood glucose , systolic blood pressure , diastolic blood pressure were significantly higher in HS group (P<0.05, P<0.01). Compared with TG+GG genotype, TT genotype population show significantly higher triglycerides concentration (P<0.05). With adjustment for hypertension, high blood sugar, and age -related factors, multivariate logistic regression analysis showed that LPL Hind III G allele could be a protective factor (OR = 0.392, 95% CI: 0.191~0.805, P = 0.011).
conclusionLPL Hind III gene polymorphism was relevant to hemorrhagic stroke. LPL Hind III G mutant allele could be a protective factor in the pathogenesis of cerebral hemorrhage.
Indexed as
Identifiers
26309627PMC4538159W1586368300What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.