ArticleInternational journal of clinical and experimental medicine2015
Meta-analysis of macrophage migration inhibitory factor (MIF) gene -173G/C polymorphism and inflammatory bowel disease (IBD) risk.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids.Frontiers in pharmacology · 2025Article
- RNA-Sequencing Reveals Gene Expression and Pathway Signatures in Umbilical Cord Blood Affected by Birth Delivery Mode.Phenomics (Cham, Switzerland) · 2023Article
- Deep Insight into the Role of MIF in Spondyloarthritis.Current rheumatology reports · 2022Review
- OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases.Journal for immunotherapy of cancer · 2022Review
- Anti-Inflammatory Activity of Oat Beta-Glucans in a Crohn's Disease Model: Time- and Molar Mass-Dependent Effects.International journal of molecular sciences · 2021Article
- The Relationship between Functional Promoter Variants of Macrophage Migration Inhibitory Factor and Endometriosis.Cell journal · 2021Article
- Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection.Anaerobe · 2018Article
- Entamoeba histolytica-Encoded Homolog of Macrophage Migration Inhibitory Factor Contributes to Mucosal Inflammation during Amebic Colitis.The Journal of infectious diseases · 2017Article
- The Mucosal Immune System and Its Regulation by Autophagy.Frontiers in immunology · 2016Review
- Impact of MIF Gene Promoter Variations on Risk of Rheumatic Heart Disease and Its Age of Onset in Saudi Arabian Patients.Frontiers in immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine associated with inflammation and inflammatory bowel disease (IBD). The association between MIF-173G/C polymorphism and IBD risk has been extensively investigated. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis. Online electronic databases (PubMed and EMBASE) was searched. All statistical tests were performed with the software STATA version 11.0 (Stata Corporation, College station, TX, USA). A total of nine studies (ten cohorts) with 3436 cases and 2742 controls were included for this meta-analysis. MIF-173G/C polymorphism was associated with a significantly increased risk of IBD when compared with CG and GG genotypes (OR=1.43; 95% CI 1.08-1.90; I(2) =0%). In the subgroup analysis according to ethnicity, significantly increased IBD risk was observed in Asians (OR=1.74; 95% CI 1.10-2.74; I(2) =0%) but not in Caucasians (OR=1.27; 95% CI 0.89-1.82; I(2) =0%). In the subgroup analysis according to IBD type, significantly increased UC risk was observed (OR=1.43; 95% CI 1.04-1.95; I(2) =0%). In conclusion, this meta-analysis suggested that MIF-173G/C polymorphism was associated with increased IBD risk.
Indexed as
Identifiers
26309626PMC4537990W1133359471What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.