ArticleInternational journal of clinical and experimental medicine2015
The association study on renalase polymorphism and hypertension: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis.PloS one · 2016Pooled it
- Article
- Molecular Role of Asn680Ser and Asp37Glu Missense Variants in Saudi Women with Female Infertility and Polycystic Ovarian Syndrome.Current issues in molecular biology · 2023Article
- Renalase: a novel regulator of cardiometabolic and renal diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.Disease markers · 2021Article
- Renalase contributes to protection against renal fibrosis via inhibiting oxidative stress in rats.International urology and nephrology · 2018Article
- Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis.Clinical interventions in aging · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is considered a multi-factorial disease since its development is affected by both genetic and environmental factors. Intensive efforts have been focused on identifying gene(s) related to hypertension. Renalase is a recently discovered protein that expressed in kidney, heart, liver, and brain that metabolizes catecholamines, regulation of blood pressure in humans and animals. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. But the reported results are not always consistent. In this meta-analysis, we examined the association between (Glu37Asp) polymorphism (rs2296545) in renalase gene and risk of hypertension. Through a systematic literature search for publications between 2007 and 2014, we summarized the data from 4 studies on polymorphism (rs2296545) in renalase gene and risk of hypertension. We did not find any association of rs2296545 with risk of hypertension in dominant model (OR=0.64; 95% CI: 0.41-1.00), recessive model (OR=1.29, 95% CI: 0.95-1.75), co-dominant model (OR=1.38, 95% CI: 0.92-2.08), and allelic model (OR=1.19; 95% CI: 0.96-1.47). The results of the present study indicated that the renalase genetic polymorphism was not associated with risk of hypertension.
Indexed as
Identifiers
26309615PMC4537962What OpenQuestion holds
Registered trials
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