Evidence map›Paper›PMID 26309610›Full record

ArticleInternational journal of clinical and experimental medicine2015

Protective effect of the ω-3 polyunsaturated fatty acids on the schistosomiasis liver fibrosis in mice.

Yuan Wu, Yu Liang, Yi Zhu, Yongqiang Gao, Hu Chen, Yukuai Zhang, Weiguo Yin, Yingju Li, Kegeng Wang, Jianhua Xiao

Abstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. A Polysaccharide from Amusium Pleuronectes Combined with Praziquantel Treatment Ameliorates Hepatic Fibrosis in Schistosoma Japonicum-Infected Mice.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yuan WuInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China ; The Second Affiliated Hospital, University of South China Hengyang 421001, Hunan, China.
Yu LiangInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
Yi ZhuThe Second Affiliated Hospital, University of South China Hengyang 421001, Hunan, China.
Yongqiang GaoInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
Hu ChenThe Second Affiliated Hospital, University of South China Hengyang 421001, Hunan, China.
Yukuai ZhangInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
Weiguo YinInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
Yingju LiInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
Kegeng WangInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
Jianhua XiaoInstitute of Pathogenic Biology of Medical College, University of South China Hengyang 421001, Hunan, China.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to observe the effect of ω-3 polyunsaturated fatty acids on initiation and elimination of the schistosomiasis inflammatory response and liver fibrosis. The mice infected with the cercariae of Schistosoma japonicum (20 ± cercarie per mice) were separated randomly into several groups. After 60 days, liver tissue samples of all mice were sectioned. Hematoxylin-eosin (HE) staining, Masson staining, the enzyme-linked immunosorbent assay (ELISA), and flow cytometry (FCM) were performed. Through HE and Masson staining, the size of egg (ovum) granuloma and the collagen deposited in mice's livers in ω-3 PUFAs and praziquantel mixed groups were less than that of model group and praziquantel treated group. The serum level of IL-13 and TNF-α were lower than that of model group and praziquantel treated group. The indicators of liver fibrosis, such as HA and LN in the group treated with ω-3 PUFAs and praziquantel before the release of soluble eggs antigen (SEA) into blood, were lower than that of model group and praziquantel treated group, respectively. The combined treatment of ω-3 polyunsaturated fatty acids and praziquantel conducted before the release of soluble eggs antigens into the blood decreases liver ovum granulomatous inflammation and fibrosis degree in the schistosomiasis. The mechanism of the ω-3 polyunsaturated fatty acid may be related to the adjustment of the anti-inflammatory and immune responses.

Indexed as

liver fibrosisprotective effectSchistosoma japonicumω-3 polyunsaturated fatty acids

Identifiers

PMID26309610
PMCPMC4537995
OpenAlexW1582901246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.