ArticleInternational journal of clinical and experimental medicine2015
The association between VEGF -634C/G polymorphisms and osteonecrosis of femoral head: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head.Molecular medicine reports · 2026Article
- The effect of endostatin on angiogenesis and osteogenesis of steroid-induced osteonecrosis of the femoral head in a rabbit model.Acta orthopaedica et traumatologica turcica · 2022Article
- The association between MCP-1, VEGF polymorphisms and their serum levels in patients with diabetic foot ulcer.Medicine · 2018Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polymorphism of the vascular endothelial growth factor (VEGF) -634C/G has been correlated with susceptibility to osteonecrosis of the femoral head (ONFH). The aim of this study was to derive a more precise estimation of the relationship between the VEGF -634C/G polymorphism and ONFH by performing a meta-analysis. We searched articles indexed in Pubmed, OVID and Web of Science published up to January 2015 that met our predefined criteria. The strength of the association between VEGF -634C/G polymorphism and ONFH risk was assessed by an odds ratio (OR) with the corresponding 95% CI. Three eligible studies involving 692 cases and 875 controls were identified. Overall, pooled analysis indicated a significant association between VEGF -634C/G polymorphism and ONFH risk (for C vs. G: OR=1.141, 95% CI 1.055-1.235, P=0.001; for CC vs. GG: OR=1.345, 95% CI 1.124-1.610, P=0.001; for CG vs. GG: OR=1.106, 95% CI 1.018-1.202, P=0.017; for CG+CC vs. GG: OR=1.104, 95% CI 1.035-1.177, P=0.003; for CC vs. GG+ CG: OR=1.294, 95% CI 1.051-1.593, P=0.015). No evidence of publication bias was observed. In conclusion, this meta-analysis suggested that polymorphism of VEGF -634C/G was a risk factor for ONFH. This finding needs further confirmation by trans-regional multicenter study with large sample in different ethnic populations, such as Caucasian and Austroloid.
Indexed as
Identifiers
26309590PMC4538152What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.