Evidence map›Paper›PMID 26309581›Full record

ArticleInternational journal of clinical and experimental medicine2015

Over-expression of TWIST, an epithelial-mesenchymal transition inducer, predicts poor survival in patients with oral carcinoma.

Yan Zhou, Huiyu Zhang, Xianlu Zhuo, Yan Liu, Gang Zhang, Yinghui Tan

Abstract read
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Biomarkers of epithelial-mesenchymal transition: E-cadherin and beta-catenin in malignant transformation of oral lesions.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yan ZhouDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University Chongqing, China.
Huiyu ZhangDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University Chongqing, China.
Xianlu ZhuoDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University Chongqing, China ; Affiliated Hospital of Guiyang Medical College Guiyang, China.
Yan LiuZunyi Health Team of Guizhou People's Armed Police Corps Zunyi, China.
Gang ZhangDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University Chongqing, China.
Yinghui TanDepartment of Stomatology, Xinqiao Hospital, Third Military Medical University Chongqing, China.
Army Medical University · CNFirst People’s Hospital of Zunyi · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TWIST, an epithelial-mesenchymal transition inducer, has been thought to play a critical role in the progression of a number of malignancies. Published studies reporting the association of TWIST expression with oral carcinoma risk has yielded conflicting results. Thus, we conducted a meta-analysis to address this controversy. After rigorous searching and screening, a total of seven studies were included. The results showed that the TWIST positive expression rate in oral cancer tissues was higher than that in the normal tissues. TWIST expression might have a correlation with clinical features such as low differentiation, advanced clinical stage, presence of lymph node metastasis and local recurrence, but not age, gender, T stage and smoking and drinking. The data suggested that TWIST might play critical roles in the cancer progression and act as a prognostic factor in oral cancer patients.

Indexed as

expressionmeta-analysismetastasisoral carcinomaTWIST

Identifiers

PMID26309581
PMCPMC4537964
OpenAlexW1526364945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.