ArticleInternational journal of clinical and experimental medicine2015
Lack of association between bcl-2 expression and prognosis of osteosarcoma: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Gene Expression Alterations Associated With Resveratrol-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Osteosarcoma Cancer Cells.Journal of cellular and molecular medicine · 2026Article
- Identification of key serum biomarkers for the diagnosis and metastatic prediction of osteosarcoma by analysis of immune cell infiltration.Cancer cell international · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies investigated the bcl-2 in prognosis of osteosarcoma, but no consistent conclusions were achieved. This meta-analysis was conducted to determine the prognostic role of bcl-2 in osteosarcoma. Databases including Pubmed, Embase, Cochrane library, Google scholar, Wanfang and CNKI were searched systematically up to March 1, 2014. Cohort studies assessing the prognostic role of bcl-2 expression in patients with osteosarcoma were included. Pooled odds ratio (OR) with 95% confidence intervals (95% CI) was adopted. Sensitivity analysis was also performed. Five studies with a total of 202 patients were included in final analysis. Compared with positive bcl-2 expression, negative bcl-2 expression was associated with better 3-year overall survival (OR=0.21, 95% CI 0.07-0.65, P=0.007). No significant difference was achieved with respect to 5-year overall survival (OR=0.76, 95% CI 0.42-1.38, P=0.264) and diseases-free survival (OR=1.20, 95% CI 0.47-3.06, P=0.709). Sensitivity analysis indicates the conclusion was stable. This meta-analysis suggests that the bcl-2 expression may be independent with the prognosis for patients with osteosarcoma. Nevertheless, additional well-designed studies with larger sample size are needed to further confirm the results.
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Identifiers
26309563PMC4538088What OpenQuestion holds
Registered trials
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