ArticleInternational journal of clinical and experimental medicine2015
Association of APOA5 T1131C polymorphism and risk of coronary artery disease.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- M235T polymorphism in the angiotensinogen gene and cardiovascular disease: An updated meta-analysis of 39 case-control comparisons.Anatolian journal of cardiology · 2019Pooled it
- Association of G894T eNOS, 4G/5G PAI and T1131C APOA5 polymorphisms with susceptibility to myocardial infarction in Morocco.Meta gene · 2016Article
- The Rise of ST-Elevation Myocardial Infarction in Women of Northeast China.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsOur research aimed to investigate the relationship between Apolipoprotein A5 (APOA5) T1131C polymorphism and the risk of coronary artery disease (CAD).
methodsWe searched the relevant articles in databases and 25 ones were chosen. The association between APOA5 T1131C polymorphism and CAD risk was evaluated using odds ratios (ORs) and 95% confidence intervals (95% CIs). The fixed-effect model or random-effect model was applied according to the heterogeneity analysis.
resultsOverall, significant association between CAD risk and APOA5 T1131C polymorphism was found (CC vs. TT: OR=1.47, 95% CI=1.22-1.78; CC+TC vs. TT: OR=1.13, 95% CI=1.07-1.20; CC vs. TT+TC: OR=1.37, 95% CI=1.13-1.66; allele C vs. allele T: OR=1.17, 95% CI=1.09-1.25; TC vs. TT: OR=1.12, 95% CI=1.06-1.20). In the ethnicity subgroup analysis, risk of CAD was observed in all genotypes among Asians (CC vs. TT: OR=1.40, 95% CI=1.17-1.68; CC+TC vs. TT: OR=1.13, 95% CI=1.06-1.20; CC vs. TT+TC: OR=1.30, 95% CI=1.08-1.56; allele C vs. allele T: OR=1.15, 95% CI=1.08-1.24; TC vs. TT: OR=1.13, 95% CI=1.06-1.21), While in Caucasians, the similar association was only found in several genotypes. In the subgroup analysis by source of control, we found that APOA5 T1131C polymorphism could increase the risk of CAD in population-based (PB) genetic group (CC vs. TT: OR=1.54, 95% CI=1.29-1.84; CC+TC vs. TT: OR=1.15, 95% CI=1.08-1.23; CC vs. TT+TC: OR=1.45, 95% CI=1.19-1.76; allele C vs. allele T: OR=1.19, 95% CI=1.12-1.25; TC vs. TT: OR=1.14, 95% CI=1.06-1.22). There was no correlation found in hospital-based (HB) genetic group yet.
conclusionAPOA5 T1131C polymorphism might be significantly associated with susceptibility to CAD.
Indexed as
Identifiers
26309551PMC4538076What OpenQuestion holds
Registered trials
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