ArticleInternational journal of clinical and experimental medicine2015
Baicalin induces apoptosis in hepatic cancer cells in vitro and suppresses tumor growth in vivo.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer.Archives of pharmacal research · 2024Pooled it
- Effects of polyphenols on cancer cell progression mediated by inhibition of cyclin-dependent kinases (CDKs): the emerging drug targets in cancer.Archives of pharmacal research · 2025Review
- Baicalin attenuated metabolic dysfunction-associated fatty liver disease by suppressing oxidative stress and inflammation via the p62-Keap1-Nrf2 signalling pathway in db/db mice.Phytotherapy research : PTR · 2025Article
- Baicalin target protein, Annexin A2, is a target of new antitumor drugs.Scientific reports · 2024Article
- Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.Journal of natural medicines · 2024Article
- Recent Advances in Biologically Active Ingredients from Natural Drugs for Sepsis Treatment.Combinatorial chemistry & high throughput screening · 2024Review
- Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities.Frontiers in pharmacology · 2024Review
- Fabrication of baicalein-encapsulated zeolitic imidazole framework as a novel nanocomposited wound closure material to persuade pH-responsive healing efficacy in post-caesarean section wound care.International wound journal · 2023Article
- Effect of Baicalin on Wound Healing in a Mouse Model of Pressure Ulcers.International journal of molecular sciences · 2022Article
- Advances in Anti-Cancer Activities of Flavonoids inInternational journal of molecular sciences · 2022Review
- Targets and Potential Mechanism ofJournal of oncology · 2022Article
- Chiral Flavonoids as Antitumor Agents.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Pharmacological properties of baicalin on liver diseases: a narrative review.Pharmacological reports : PR · 2021Review
- The Use of Chinese Skullcap (Animals : an open access journal from MDPI · 2021Review
- Folic Acid Decorated Zeolitic Imidazolate Framework (ZIF-8) Loaded with Baicalin as a Nano-Drug Delivery System for Breast Cancer Therapy.International journal of nanomedicine · 2021Article
- Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer.Oncotarget · 2020Article
- Retracted Article: Synthesis of xanthone derivatives and anti-hepatocellular carcinoma potency evaluation: induced apoptosis.RSC advances · 2019Article
- Baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the AKT pathway.Oncology letters · 2019Article
- Polymeric nanocapsular baicalin: Chemometric optimization, physicochemical characterization and mechanistic anticancer approaches on breast cancer cell lines.Scientific reports · 2019Article
- Effect of baicalin on proliferation and apoptosis in pancreatic cancer cells.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Baicalin is a flavonoid glycoside extracted from a kind of traditional Chinese drug, Scutellaria baicalensis, and possesses multiple pharmacological activities. The present study was designed to investigate the effects and mechanisms of baicalin against hepatic cancer cell growth and survival. We found that baicalin inhibited the viability and proliferation of two widely used hepatic cancer cell lines, Hep G2 and SMMC-7721 cells, in a dose-dependent manner. Cell cycle analysis revealed an increase in the S-phase cell population following 48 h exposure to baicalin. The expression levels of Cyclin A, CDK2, and Cyclin D1 were downregulated by baicalin treatment. Moreover, baicalin induced apoptotic cell death in Hep G2 and SMMC-7721 cells, which was accompanied by upregulation of Bax, downregulation of Bcl-2, and cleavages of Caspase-9, Caspase-3, and PARP. Furthermore, baicalin significantly inhibited the growth of xenografts in nude mice. In conclusion, we demonstrated for the first time that baicalin inhibited hepatic cancer cell growth and survival both in vitro and in vivo, suggesting that baicalin may be a potential phytochemical flavonoid for hepatic cancer therapy.
Indexed as
Identifiers
26309548PMC4538000W1466860153What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.