ArticleInternational journal of clinical and experimental medicine2015
Association between the TNF-α G-308A polymorphism and risk of ischemic heart disease: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Pooled it
- Tumor necrosis factor-alpha gene polymorphisms and susceptibility to ischemic heart disease: A systematic review and meta-analysis.Medicine · 2017Pooled it
- Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients.Journal, genetic engineering & biotechnology · 2023Article
- TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.Molecular biology reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the tumor necrosis factor-α (TNF-α) G-308A polymorphism in the risk of ischemic heart disease (IHD) has been controversial in recent decades. A substantial number of newly-published studies concerning the association between the TNF-α polymorphism and IHD risk have emerged after the publication of the latest meta-analysis. Therefore, we conducted an updated meta-analysis to further investigate the influence of this polymorphism on IHD.
methodsElectronic databases (PubMed, Embase, CNKI, and Wanfang) were systematically searched to identify all relevant papers published before September 25(th), 2014. The quality of all eligible studies was assessed. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) of all studies and high-quality studies were assessed by the fixed/random-effects model in Review Manager 5.0.25 and STATA 10.0. Heterogeneity and publication bias were detected; sensitivity analysis was conducted.
resultsData from 36 studies were recorded after study selection and exclusion. Under the dominant model, the results of pooled analysis of high-quality studies suggested that the G-308A polymorphism was associated with an increased risk of IHD in total population (P = 0.02, OR = 1.13, 95% CI = 1.02-1.24, P heterogeneity = 0.009, I(2) = 45%). No significant result was obtained in Asians, Caucasians, or Indians.
conclusionThe TNF-α -308A allele is probably associated with an increased risk of IHD in total population, but to further identify this association, more high quality studies in Indians and Africans are merited.
Indexed as
Identifiers
26309542PMC4538071W1197636409What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.