ArticleInternational journal of clinical and experimental medicine2015
Insights into the molecular mechanisms of methylmalonic acidemia using microarray technology.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Metabolic toxicity and neurological dysfunction in methylmalonic acidemia: from mechanisms to therapeutics.Molecular medicine (Cambridge, Mass.) · 2025Review
- Improving the second-tier classification of methylmalonic acidemia patients using a machine learning ensemble method.World journal of pediatrics : WJP · 2024Article
- Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria.BMC geriatrics · 2024Article
- Methylmalonic acidemia: Neurodevelopment and neuroimaging.Frontiers in neuroscience · 2023Review
- The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice.Oxidative medicine and cellular longevity · 2022Review
- Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes.Frontiers in nutrition · 2022Article
- The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme QInternational journal of molecular sciences · 2020Article
- Hyperammonaemia in classic organic acidaemias: a review of the literature and two case histories.Orphanet journal of rare diseases · 2018Review
- TAT-MTS-MCM fusion proteins reduce MMA levels and improve mitochondrial activity and liver function in MCM-deficient cells.Journal of cellular and molecular medicine · 2018Article
- Newborn Screening for Methylmalonic Acidemia in a Chinese Population: Molecular Genetic Confirmation and Genotype Phenotype Correlations.Frontiers in genetics · 2018Article
- Parkinsonism in Inherited Metabolic Disorders: Key Considerations and Major Features.Frontiers in neurology · 2018Review
- "Classical organic acidurias": diagnosis and pathogenesis.Clinical and experimental medicine · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylmalonic acidemia (MMA) is widely considered as an autosomal recessive metabolic disorder that results in accumulation of high levels of methylmalonic acid and eventually brain damage. This study aims to investigate the effects of methylmalonic acid on neurons and analyze various gene expression profiles in rat cortical neurons treated with methylmalonic acid in order to understand the effects of MMA. High concentrations of methylmalonic acid could significantly alter the morphology of rat cortical neurons, attenuate cell viability and aggravate cell apoptosis. Moreover, 564 differentially expressed genes were identified by microarray analysis. A considerable number of these genes were apoptosis-related genes. Enrichment analysis of the apoptosis-related genes revealed that the MAPK and p53 signaling pathways may be involved in the pathogenesis of MMA. Our results together reveal that methylmalonic acid plays a critical role in neuron damage and that the MAPK and p53 signaling pathways may be involved in the mechanism of MMA.
Indexed as
Identifiers
26309541PMC4538064W1567262803What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.