ArticlePopulation health metrics2015
Multiple causes of death analysis of chronic diseases: the example of diabetes.
Article in Population health metrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Diabetes-related mortality in the immigrant compared to the Italian population, before and during the pandemic.Journal of endocrinological investigation · 2025Article
- Are contributory causes of death in part 2 of the death certificate mediators of chains of morbid events leading to death?Population health metrics · 2025Article
- Association of early-onset diabetes with socioeconomic, and health factors: a matched case-control study controlling for age, gender, and BMI.Journal of diabetes and metabolic disorders · 2025Article
- Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality.Scientific reports · 2024Article
- Cardiovascular Disease and Diabetes Are Among the Main Underlying Causes of Death in Twenty Healthcare Facilities Across Two Cities in the Democratic Republic of Congo.International journal of environmental research and public health · 2024Article
- Ischemic heart disease-related mortality in Brazil, 2006 to 2020. A study of multiple causes of death.BMC public health · 2024Article
- Effects of inappropriate cause-of-death certification on mortality from cardiovascular disease and diabetes mellitus in Tonga.BMC public health · 2023Article
- Quantifying cause-related mortality in Australia, incorporating multiple causes: observed patterns, trends and practical considerations.International journal of epidemiology · 2023Article
- Diabetes as a cause of death across different COVID-19 epidemic waves.Diabetes research and clinical practice · 2022Article
- Time series of diabetes attributable mortality from 2008 to 2017.Journal of endocrinological investigation · 2022Article
- Proton pump inhibitors and risk of all-cause and cause-specific mortality: A cohort study.British journal of clinical pharmacology · 2021Article
- Trends in diabetes mortality identified from death certificates in Colombia, 1979-2017.Revista panamericana de salud publica = Pan American journal of public health · 2021Article
- Estimating a Set of Mortality Risk Functions with Multiple Contributing Causes of Death.Epidemiology (Cambridge, Mass.) · 2020Article
- Why are epilepsy mortality rates rising in the United States? A population-based multiple cause-of-death study.BMJ open · 2020Article
- Trends in systemic sclerosis and systemic sclerosis-related pulmonary arterial hypertension mortality in the USA.ERJ open research · 2020Article
- Article
- Trends in overall, cardiovascular and cancer-related mortality among individuals with diabetes reported on death certificates in the United States between 2007 and 2017.Diabetologia · 2019Article
- Sex differences and risk factors for diabetes mellitus - an international study from 193 countries.Globalization and health · 2018Article
- Factors Associated With County-Level Differences in U.S. Drug-Related Mortality Rates.American journal of preventive medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentifying a single disease as the underlying cause of death (UCOD) is an oversimplification of the clinical-pathological process leading to death. The multiple causes of death (MCOD) approach examines any mention of a disease in death certificates. Taking diabetes as an example, the study investigates: patterns of death certification, differences in mortality figures based on the UCOD and on MCOD, factors associated to the mention of diabetes in death certificates, and potential of MCOD in the analysis of the association between chronic diseases.
methodsThe whole mortality archive of the Veneto Region-Italy was extracted from 2008 to 2010. Mortality rates and proportional mortality were computed for diabetes as the UCOD and as MCOD. The position of the death certificate where diabetes was mentioned was analyzed. Conditional logistic regression was applied with chronic liver diseases (CLD) as the outcome and diabetes as the exposure variable. A subset of 19,605 death certificates of known diabetic patients (identified from the archive of exemptions from medical charges) was analyzed, with mention of diabetes as the outcome and characteristics of subjects as well as other diseases reported in the certificate as predictors.
resultsIn the whole mortality archive, diabetes was mentioned in 12.3 % of death certificates, and selected as the UCOD in 2.9 %. The death rate for diabetes as the UCOD was 26.8 × 10(5) against 112.6 × 10(5) for MCOD; the UCOD/MCOD ratio was higher in males. The major inconsistencies of certification were entering multiple diseases per line and reporting diabetes as a consequence of circulatory diseases. At logistic regression the mention of diabetes was associated with the mention of CLD (mainly non-alcohol non-viral CLD). In the subset of known diabetic subjects, diabetes was reported in 52.1 %, and selected as the UCOD in 13.4 %. The probability of reporting diabetes was higher with coexisting circulatory diseases and renal failure and with long duration of diabetes, whereas it was lower in the presence of a neoplasm.
conclusionsThe use of MCOD makes the analysis of mortality data more complex, but conveys more information than usual UCOD analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.