Evidence map›Paper›PMID 26309358›Full record

ArticleWorld journal of gastroenterology2015

Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer.

Byung Joon Choi, Jung Hwan Yoon, Olga Kim, Won Suk Choi, Suk Woo Nam, Jung Young Lee, Won Sang Park

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023
    Review
  8. TERT genetic polymorphismFrontiers in surgery · 2022
    Article
  9. Implications of risk conferred by 5p15.33 loci genetic variants; human telomerase reverse transcriptase rs2736098 and rs2736100 in predisposition of bladder cancer.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Article
  10. Association betweenCancer cell international · 2020
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Byung Joon ChoiByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Jung Hwan YoonByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Olga KimByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Won Suk ChoiByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Suk Woo NamByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Jung Young LeeByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Won Sang ParkByung Joon Choi, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the functional consequences of rs2736100 polymorphism in telomere length and examine its link to gastric cancer risk.

methodsTelomere length and human telomerase reverse transcriptase (hTERT) mRNA expression were measured in 35 gastric cancer tissues and 5 cell lines and correlated to rs2736100 polymorphism. The relationship between rs2736100 polymorphism and the risk of gastric cancer were examined in 243 gastric cancer patients and 246 healthy individuals.

resultsThe rs2736100 A allele carrier is closely associated with reduced hTERT mRNA expression and shortened telomere length in gastric cancer tissue and cell lines. When gastric cancers were stratified by histological subtype, telomere length and hTERT mRNA levels were significantly increased in those with the C/C genotype in intestinal-type gastric cancer, but not in diffuse-type gastric cancer. Interestingly, there was no significant difference in the genotype and allele frequencies of the rs2736100 polymorphism between the patients with gastric cancer and healthy controls.

conclusionThe rs2736100 polymorphism of the hTERT gene is involved in the regulation of hTERT expression and telomere length, but not in the risk of gastric cancer.

Indexed as

Polymorphism, Single NucleotideTelomere HomeostasisAdenocarcinomaAdultAgedAged, 80 and overCase-Control StudiesCell Line, TumorFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedPhenotypeRisk FactorsTelomeraseTERT protein, humanGastric cancerHuman telomerase reverse transcriptasePolymorphismRiskTelomere

Identifiers

PMID26309358
PMCPMC4541384
OpenAlexW1179407956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.