ArticleColombia medica (Cali, Colombia)
C677T (RS1801133 ) MTHFR gene polymorphism frequency in a colombian population.
Article in Colombia medica (Cali, Colombia). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
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- Identification of crucial genes involved in thyroid cancer development.Journal of the Egyptian National Cancer Institute · 2023Review
- The Future of Precision Medicine in the Cure of Alzheimer's Disease.Biomedicines · 2023Review
- The association ofFrontiers in genetics · 2022Article
- The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.Saudi journal of biological sciences · 2021Article
- Pharmacogenetic aspects of methotrexate in a cohort of Colombian patients with rheumatoid arthritis.Biomedical reports · 2020Article
- Ethnogeographic prevalence and implications of the 677C>T and 1298A>CBiomarkers in medicine · 2019Article
- Analysis of genetic polymorphism of methylenetetrahydrofolate reductase in a large ethnic Hakka population in southern China.Medicine · 2018Article
- Precision Medicine for Alzheimer's Disease Prevention.Healthcare (Basel, Switzerland) · 2018Review
- Distribution ofIndian journal of clinical biochemistry : IJCB · 2017Article
- Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.BMC ophthalmology · 2016Article
- Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2016Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAbnormal levels of the enzyme methylenetetrahydrofolate reductase (MTHFR) are associated with an increased risk of both cardiovascular and cerebrovascular disease and higher concentrations of homocysteine. Abnormal levels are also related to birth defects, pregnancy complications, cancer and toxicity to methotrexate (MTX). Polymorphisms of MTHFR affect the activity of the enzyme. Genetic associations have been related to treatment efficacy.
objectiveTo establish the frequency of the C> T polymorphism at nucleotide 677 of the MTHFR gene in a group of Colombian individuals.
methodsData from pharmacogenetic microarrays that include MTX sensibility-associated polymorphisms were retrospectively collected (Pathway Genomics(®)). The frequency of the C> T MTHFR rs1801133 marker polymorphism was analyzed.
resultsMicroarray data from 68 men and 84 women were analyzed. Comparisons of genotype C/C vs. C/T and T/T were statistically significantly different (p= 0.00, p= 0.026, respectively), as were C/T and T / T (p= 0.0001).
conclusionsResults for the C/C and C/T genotypes in a Colombian population are similar to other previously studied groups of healthy subjects. Subjects from our population might be at risk of developing diseases associated with MTHFR polymorphisms and might present toxicity and adverse effects if treated with MTX, which suggests the need to evaluate therapeutic alternatives based on individual pharmacogenetic studies.
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26309343PMC4536819W2162336912What OpenQuestion holds
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