Observational studyPloS one2015
Seizure Outcomes and Predictors of Recurrent Post-Stroke Seizure: A Retrospective Observational Cohort Study.
Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Antiseizure Medications in Poststroke Seizures: A Systematic Review and Network Meta-Analysis.Neurology · 2025Pooled it
- Outcomes of patients with post-stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence.Epilepsia open · 2026Review
- Associations of Stroke With Risk of Epilepsy: Results From the Atherosclerosis Risk in Communities (ARIC) Study.Annals of clinical and translational neurology · 2025Article
- Observational
- Post-stroke seizures: risk factors and management after ischemic stroke.Acta neurologica Belgica · 2023Article
- Risk Factors Associated with Epilepsy Related to Cerebrovascular Disease: A Systematic Review and Meta-Analysis.Neuropsychiatric disease and treatment · 2023Review
- Interictal epileptiform discharges as a predictive biomarker for recurrence of poststroke epilepsy.Brain communications · 2022Article
- Recurrence risk after a first remote symptomatic seizure in adults: Epilepsy or not?Epilepsia open · 2021Review
- Antiseizure medications for post-stroke epilepsy: A real-world prospective cohort study.Brain and behavior · 2021Article
- Characteristics of the patients who admitted to the emergency department with seizures and the factors affecting the frequency of admission.Neurosciences (Riyadh, Saudi Arabia) · 2021Article
- Visualizing prolonged hyperperfusion in post-stroke epilepsy using postictal subtraction SPECT.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Predictors of Function, Activity, and Participation of Stroke Patients Undergoing Intensive Rehabilitation: A Multicenter Prospective Observational Study Protocol.Frontiers in neurology · 2021Article
- Investigation of poststroke epilepsy (INPOSE) study: a multicenter prospective study for prediction of poststroke epilepsy.Journal of neurology · 2020Article
- MicroRNA Regulatory Network as Biomarkers of Late Seizure in Patients with Spontaneous Intracerebral Hemorrhage.Molecular neurobiology · 2020Article
- Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure.Neuropsychiatric disease and treatment · 2020Article
- Predictors of Seizure Recurrence after Acute Symptomatic Seizures in Ischemic Stroke Patients.Neuroscience journal · 2019Article
- Poststroke epilepsy: current perspectives on diagnosis and treatment.Neuropsychiatric disease and treatment · 2019Review
- Risk Factors for Epilepsy After Thrombolysis for Ischemic Stroke: A Cohort Study.Frontiers in neurology · 2019Article
- Association between different acute stroke therapies and development of post stroke seizures.BMC neurology · 2018Article
- Short duration of focal onset awareness and impaired awareness seizure are characteristic features of epilepsy in elderly patients.Neuropsychiatric disease and treatment · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeizure is a common complication after stroke (termed "post-stroke seizure," PSS). Although many studies have assessed outcomes and risk factors of PSS, no reliable predictors are currently available to determine PSS recurrence. We compared baseline clinical characteristics and post-stroke treatment regimens between recurrent and non-recurrent PSS patients to identify factors predictive of recurrence.
methodsConsecutive PSS patients admitted to our stroke center between January 2011 and July 2013 were monitored until February 2014 (median 357 days; IQR, 160-552) and retrospectively evaluated for baseline clinical characteristics and PSS recurrence. Cumulative recurrence rates at 90, 180, and 360 days post-stroke were estimated by Kaplan-Meier analysis. Independent predictors of recurrent PSS were identified by Cox proportional-hazards analysis.
resultsA total of 104 patients (71 men; mean age, 72.1 ± 11.2 years) were analyzed. PSS recurred in 31 patients (30%) during the follow-up. Factors significantly associated with PSS recurrence by log-rank analysis included previous PSS, valproic acid (VPA) monotherapy, polytherapy with antiepileptic drugs (AEDs), frontal cortical lesion, and higher modified Rankin Scale score at discharge (all p < 0.05). Independent predictors of recurrent PSS were age <74 years (HR 2.38, 95% CI 1.02-5.90), VPA monotherapy (HR 3.86, 95% CI 1.30-12.62), and convulsions on admission (HR 3.87, 95% CI 1.35-12.76).
conclusionsApproximately one-third of PSS patients experienced seizure recurrence within one year. The predictors of recurrent PSS were younger age, presence of convulsions and VPA monotherapy. Our findings should be interpreted cautiously in countries where monotherapy with second-generation AEDs has been approved because this study was conducted while second-generation AEDs had not been officially approved for monotherapy in Japan.
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