ArticlePloS one2015
Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Discriminating severe seasonal allergic rhinitis. Results from a large nation-wide database.PloS one · 2018Trial
- Distinction between allergic rhinitis alone and allergic rhinitis + asthma in MASK-air® real-world studies; a ARIA-WAO task force review.The World Allergy Organization journal · 2026Review
- Multidimensional characterization of allergic rhinitis in Mysuru, South India: A cluster-based approach.The journal of allergy and clinical immunology. Global · 2026Article
- Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review.Journal of asthma and allergy · 2025Review
- Infertility, IL-17, IL-33 and Microbiome Cross-Talk: The Extended ARIA-MeDALL Hypothesis.International journal of molecular sciences · 2024Review
- Trajectory analysis of rhinitis in a birth cohort from lower-income New York City neighborhoods.The Journal of allergy and clinical immunology · 2024Article
- Distinction between rhinitis alone and rhinitis with asthma using interactomics.Scientific reports · 2023Article
- Rhinitis phenotypes and multimorbidities in the general population: the CONSTANCES cohort.The European respiratory journal · 2023Article
- Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-airClinical and translational allergy · 2023Article
- Exploring Common Symptoms in Patients with Respiratory Allergies Using K-Means Algorithm in the North-East of Iran in 2012-2015.Tanaffos · 2023Article
- Distinct Endotypes of Pediatric Rhinitis Based on Cluster Analysis.Allergy, asthma & immunology research · 2022Article
- Worldwide prevalence of rhinitis in adults: A review of definitions and temporal evolution.Clinical and translational allergy · 2022Review
- Trajectories of childhood immune development and respiratory health relevant to asthma and allergy.eLife · 2018Article
- Review
- ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle.Clinical and translational allergy · 2016Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe classification of rhinitis in adults is missing in epidemiological studies.
objectiveTo identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.
methods983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used. Allergic sensitization was defined by at least one positive skin prick test to 12 aeroallergens. Mixture model was used to cluster participants, independently in those without (Asthma-, n = 582) and with asthma (Asthma+, n = 401).
resultsThree clusters were identified in both groups: 1) Cluster A (55% in Asthma-, and 22% in Asthma+) mainly characterized by the absence of nasal symptoms, 2) Cluster B (23% in Asthma-, 36% in Asthma+) mainly characterized by nasal symptoms all over the year, sinusitis and a low prevalence of positive skin prick tests, and 3) Cluster C (22% in Asthma-, 42% in Asthma+) mainly characterized by a peak of nasal symptoms during spring, a high prevalence of positive skin prick tests and a high report of hay fever, allergic rhinitis and conjunctivitis. The highest rate of polysensitization (80%) was found in participants with comorbid asthma and allergic rhinitis.
conclusionThis cluster analysis highlighted three clusters of rhinitis with similar characteristics than those known by clinicians but differing according to allergic sensitization, and this whatever the asthma status. These clusters could be easily rebuilt using a small number of variables.
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