ReviewNature neuroscience2015
Optogenetics: 10 years of microbial opsins in neuroscience.
Review in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 588 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
588 citing papers in PubMed.
- Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.Journal of neuroscience methods · 2026Article
- From optical control to translational readiness: an evidence-tiered framework for optogenetics in neuromuscular and neurological disorders.Materials today. Bio · 2026Review
- Article
- Evolution and Reorganization of the Hierarchical Brain-wide Neuronal Network Through Anesthesia.Neuroscience bulletin · 2026Article
- Optogenetic vision restoration: translational barriers and emerging therapeutic strategies.Gene therapy · 2026Review
- Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026Review
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Wireless, Adaptable and Fully Implantable Battery-powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Protocol for intra-nerve AAV injection and dorsal root potential recording for optogenetic modulation of the peripheral sensory nerve activity.STAR protocols · 2026Article
- Light-Modulated Xylan-Reinforced Nanofluidic Memristor for Ionic Neural Network-Based Robot Movement Modulation.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- X-optogenetic inhibition of VTA GABA neurons for wireless deep-brain stimulation and suppression of scratching behavior in freely moving mice.Materials today. Bio · 2026Article
- STIMscope: centimeter-scale all-optical imaging and patterned optogenetic manipulation at single-cell resolution.bioRxiv : the preprint server for biology · 2026Article
- Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.bioRxiv : the preprint server for biology · 2026Article
- Multicolored, Sonosensitizer-Optimized Organic Mechanoluminescent Nanoparticles for Functional Sono-Optogenetics.Journal of the American Chemical Society · 2026Article
- Article
- High-power dual-channel chamber for high-frequency magnetic neuromodulation.Journal of neural engineering · 2026Article
- Magnetoelectric Nanoparticle-Based Wireless Brain-Computer Interface: Underlying Physics and Projected Technology Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Over 1.65 GW cmLight, science & applications · 2026Article
- Control of cortical population activity with patterned microstimulation.bioRxiv : the preprint server for biology · 2026Article
- Review
528 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Over the past 10 years, the development and convergence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical strategies for guiding light through tissue have enabled versatile optical control of defined cells in living systems, defining modern optogenetics. Despite widespread recognition of the importance of spatiotemporally precise causal control over cellular signaling, for nearly the first half (2005-2009) of this 10-year period, as optogenetics was being created, there were difficulties in implementation, few publications and limited biological findings. In contrast, the ensuing years have witnessed a substantial acceleration in the application domain, with the publication of thousands of discoveries and insights into the function of nervous systems and beyond. This Historical Commentary reflects on the scientific landscape of this decade-long transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.