Neurodegeneration: Problems at the nuclear pore.

Bennett W Fox, Randal S Tibbetts

Abstract readComment

In one paragraph

Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis.The EMBO journal · 2021
Review
Functions of Gle1 are governed by two distinct modes of self-association.The Journal of biological chemistry · 2020
Article
Analysis of a Strong Suppressor of Segregation Distorter inGenetics · 2020
Article
Pathogenic Variants in NUP214 Cause "Plugged" Nuclear Pore Channels and Acute Febrile Encephalopathy.American journal of human genetics · 2019
Article
Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.Cold Spring Harbor perspectives in medicine · 2017
Review
There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS.Brain research · 2016
Review
An amyotrophic lateral sclerosis-linked mutation in GLE1 alters the cellular pool of human Gle1 functional isoforms.Advances in biological regulation · 2016
Article

4 · The record

Corrections and comments

Comment on
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.2015
Comment on
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.2015

5 · Who and what money

Authors and funding

2 authors.

Bennett W FoxDepartment of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Randal S TibbettsDepartment of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Funding

Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023

$9.8M

NIGMS NIH HHS T32 GM008505

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Active Transport, Cell NucleusAnimalsC9orf72 ProteinCell NucleusDNA Repeat ExpansionDrosophila melanogasterFemaleHumansMaleOpen Reading FramesProteinsRNA TransportC9orf72 ProteinC9orf72 protein, humanProteins

Identifiers

PMID26308896

DOI10.1038/nature15208

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.