Evidence map›Paper›PMID 26308876›Full record

ArticleJournal of veterinary internal medicine

Association of Vitamin D Status and Clinical Outcome in Dogs with a Chronic Enteropathy.

H Titmarsh, A G Gow, S Kilpatrick, J Sinclair, T Hill, E Milne, A Philbey, J Berry, I Handel, R J Mellanby

Erratum issuedAbstract read
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Chronic Enteropathy and Vitamins in Dogs.Animals : an open access journal from MDPI · 2025
    Review
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  8. Article
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  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Vitamin D status in cats with cardiomyopathy.Journal of veterinary internal medicine · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

H TitmarshRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
A G GowRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
S KilpatrickRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
J SinclairRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
T HillRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
E MilneRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
A PhilbeyRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
J BerryVitamin D Research Laboratory, Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre, Manchester Royal Infirmary, Manchester, UK.
I HandelRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
R J MellanbyRoyal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundDogs with a chronic enteropathy (CE) have a lower vitamin D status, than do healthy dogs. Vitamin D status has been associated with a negative clinical outcome in humans with inflammatory bowel disease.

objectivesTo examine the relationship between serum 25 hydroxyvitamin D (25(OH)D) concentrations at diagnosis and clinical outcome in dogs with a CE. ANIMALS: Forty-one dogs diagnosed with CE admitted to the Royal Dick School of Veterinary Studies, Hospital for Small Animals between 2007 and 2013.

methodsRetrospective review. Serum 25(OH)D concentrations were compared between dogs which were alive at follow up or had died because of non-CE-related reasons (survivors) and dogs which died or were euthanized due to their CE (non-survivors). A binary logistic regression analysis was performed to determine significant predictors of death in dogs with CE.

resultsSerum concentrations of 25(OH)D at the time a CE was diagnosed were significantly lower in nonsurvivors (n = 15) (median nonsurvivors 4.36 ng/mL, interquartile range 1.6-17.0 ng/mL), median survivors (n = 26) (24.9 ng/mL interquartile range 15.63-39.45 ng/mL, P < .001). Serum 25(OH)D concentration was a significant predictor of death in dogs with CE (odds ratio 1.08 [95% CI 1.02-1.18)]).

conclusionsSerum 25(OH)D concentrations at diagnosis are predictive of outcome in dogs with CE. The role of vitamin D in the initiation and outcome of chronic enteropathies in dogs is deserving of further study.

Indexed as

AnimalsChronic DiseaseDog DiseasesDogsEnteritisFemaleMaleRetrospective StudiesVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D25 (OH)DInflammatory bowel diseasePrognostic

Identifiers

PMID26308876
PMCPMC4895651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.