ArticlePloS one2015
Intracochlear Bleeding Enhances Cochlear Fibrosis and Ossification: An Animal Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Understanding the Mechanisms Driving Fibrosis Following Cochlear Implantation-Lessons from Other Tissues.Cells · 2025Review
- Quantifying Residual Hearing Loss from Electrode Insertion Trauma in Cochlear Implant Surgery: A Prospective Double-Blind Study.The journal of international advanced otology · 2025Observational
- Bilateral intracochlear hemorrhage: A rare onset of chronic myelogenous leukemia.Clinical case reports · 2024Article
- Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation.Laryngoscope investigative otolaryngology · 2023Article
- Using x-ray micro computed tomography to quantify intracochlear fibrosis after cochlear implantation in a Guinea pig model.Heliyon · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Purification of Fibroblasts From the Spiral Ganglion.Frontiers in neurology · 2022Article
- Relationships between Intrascalar Tissue, Neuron Survival, and Cochlear Implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Magnetically Steered Robotic Insertion of Cochlear-Implant Electrode Arrays: System Integration and First-In-Cadaver Results.IEEE robotics and automation letters · 2020Article
- Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials.Laryngoscope investigative otolaryngology · 2019Review
- Susceptibility of Diabetic Mice to Noise Trauma.BioMed research international · 2018Article
- Effects of dexamethasone on intracochlear inflammation and residual hearing after cochleostomy: A comparison of administration routes.PloS one · 2018Article
- Influence of electrode array stiffness and diameter on hearing in cochlear implanted guinea pig.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effects of intracochlear bleeding during cochleostomy on cochlear inflammatory response and residual hearing in a guinea pig animal model. Auditory brainstem response threshold shifts were greater in blood injected ears (p<0.05). Interleukin-1β, interleukin-10, tumor necrosis factor-α and nitric oxide synthase 2, cytokines that are related to early stage inflammation, were significantly increased in blood injected ears compared to normal and cochleostomy only ears at 1 day after surgery; with the increased IL-1β being sustained until 3 days after the surgery (p<0.05). Hair cells were more severely damaged in blood injected ears than in cochleostomy only ears. Histopathologic examination revealed more extensive fibrosis and ossification in blood injected ears than cochleostomy only ears. These results show that intracochlear bleeding enhanced cochlear inflammation resulting in increased fibrosis and ossification in an experimental animal model.
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Registered trials
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