ArticleAngewandte Chemie (International ed. in English)2015
Ortho-Stabilized (18) F-Azido Click Agents and their Application in PET Imaging with Single-Stranded DNA Aptamers.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
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- Iodoarene Activation: Take a Leap Forward toward Green and Sustainable Transformations.Chemical reviews · 2025Review
- SyntheticRSC medicinal chemistry · 2024Review
- Quantitative Evaluation of a Multimodal Aptamer-Targeted Long-Circulating Polymer for Tumor Targeting.ACS omega · 2023Article
- Exploring the role of halogen bonding in iodonium ylides: insights into unexpected reactivity and reaction control.Beilstein journal of organic chemistry · 2023Review
- Radiochemical Synthesis of 4-[Molecules (Basel, Switzerland) · 2022Article
- Site-Specific Radioiodination of Oligonucleotides with a Phenolic Element in a Programmable Approach.Molecules (Basel, Switzerland) · 2022Article
- Advances in aptamer-based nuclear imaging.European journal of nuclear medicine and molecular imaging · 2022Review
- Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design.Frontiers in chemistry · 2022Review
- Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.Journal of medicinal chemistry · 2021Review
- Design, Synthesis, and Evaluation ofJournal of medicinal chemistry · 2019Article
- FacileNature protocols · 2019Article
- Chemistry for Positron Emission Tomography: Recent Advances inAngewandte Chemie (International ed. in English) · 2019Review
- Dynamic, Bioresponsive Hydrogels via Changes in DNA Aptamer Conformation.Macromolecular bioscience · 2019Article
- Targeted Molecular Imaging Using Aptamers in Cancer.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation.Bioorganic & medicinal chemistry · 2018Article
- In Vitro and in Vivo Evaluation ofJournal of medicinal chemistry · 2018Article
- Hypervalent aryliodine compounds as precursors for radiofluorination.Journal of labelled compounds & radiopharmaceuticals · 2018Review
- Review
- Streamlined asymmetric α-difunctionalization of ynones.Nature communications · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Azido (18) F-arenes are important and versatile building blocks for the radiolabeling of biomolecules via Huisgen cycloaddition ("click chemistry") for positron emission tomography (PET). However, routine access to such clickable agents is challenged by inefficient and/or poorly defined multistep radiochemical approaches. A high-yielding direct radiofluorination for azido (18) F-arenes was achieved through the development of an ortho-oxygen-stabilized iodonium derivative (OID). This OID strategy addresses an unmet need for a reliable azido (18) F-arene clickable agent for bioconjugation reactions. A ssDNA aptamer was radiolabeled with this agent and visualized in a xenograft mouse model of human colon cancer by PET, which demonstrates that this OID approach is a convenient and highly efficient way of labeling and tracking biomolecules.
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Registered trials
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