Evidence map›Paper›PMID 26308599›Full record

ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2015

Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis.

Run Tong, Lin Feng, Lei Zhang, Jianzhi Zhang, Yousheng Mao, Kaitai Zhang, Yanning Gao, Guiqi Wang, Shujun Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Run Tong1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Lin Feng1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Lei Zhang2 Department of Endoscopy, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Jianzhi Zhang3 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery, Peking University School of Oncology , Beijing Cancer Hospital & Institute, Beijing, P.R. China .
Yousheng Mao4 Department of Thoracic Surgery, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Kaitai Zhang1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Yanning Gao1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Guiqi Wang2 Department of Endoscopy, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Shujun Cheng1 State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
Chinese Academy of Medical Sciences & Peking Union Medical College · CNMinistry of Education · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence suggests that interferon (IFN) alpha/beta are involved in antitumor immunity and cancer immunoediting, but information on the antitumor effects of IFN alpha/beta in lung cancer is limited. In our study, we elucidated the IFN alpha/beta signature during both human fetal lung development and lung tumorigenesis. Our findings indicated gradual upregulation in the IFN alpha/beta signature during human fetal lung development. In addition, this signature was progressively downregulated in normal human airway epithelial cells from lung cancer patients, in immortalized human bronchial epithelial cell lines from later passages, in late-stage lung squamous cell carcinoma (LSCC) tissues, and in LSCC tissues exhibiting lymph node metastasis. Therefore, from its earliest stages, lung tumorigenesis may be associated with a decreased IFN alpha/beta signature. This association may provide insight to guide the detection of high-risk lung cancer patients.

Indexed as

Cell LineCell Transformation, NeoplasticComputational BiologyDatasets as TopicDown-RegulationEpithelial CellsGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Expression Regulation, NeoplasticHumansInterferon-alphaInterferon-betaLung NeoplasmsNeoplasm MetastasisNeoplasm StagingRespiratory MucosaInterferon-alphaInterferon-beta

Identifiers

PMID26308599
PMCPMC4683557
OpenAlexW1783330161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.