Evidence map›Paper›PMID 26308317›Full record

ReviewJournal of pediatric gastroenterology and nutrition2015

Prevalence and Health Outcomes of Functional Gastrointestinal Symptoms in Infants From Birth to 12 Months of Age.

Yvan Vandenplas, Abdelhak Abkari, Marc Bellaiche, Marc Benninga, Jean Pierre Chouraqui, FügenÇullu Çokura, Tracy Harb, Badriul Hegar, Carlos Lifschitz, Thomas Ludwig and 8 more

Erratum issued Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pediatric gastroenterology and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05829720 (A Double-blind, Parallel Designed, Randomized Controlled Trial to Investigate Effects of Conventional Vs A2 Milk on Breastmilk Composition and Subsequent Infant Gut Health, Crying and Sleep Patterns in Healthy, Full-term Infants), which is not on this map. Cited by 105 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 6 pooled it
43.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05829720 nacompletednot on this mapstarted 2023, after this paper: background citation

A Double-blind, Parallel Designed, Randomized Controlled Trial to Investigate Effects of Conventional Vs A2 Milk on Breastmilk Composition and Subsequent Infant Gut Health, Crying and Sleep Patterns in Healthy, Full-term Infants

TypeinterventionalSponsora2 Milk Company Ltd.Ran2023 to 2023Enrolled100ConditionsDigestive System Disease, Sleepiness, CryingArmsa2 Full Cream Milk, Conventional Milk (Weidendorf)
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 6 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Probiotics to prevent infantile colic.The Cochrane database of systematic reviews · 2019
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  3. Dietary modifications for infantile colic.The Cochrane database of systematic reviews · 2018
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  14. Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants.International journal of environmental research and public health · 2019
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

18 authors at 16 institutions in 15 countries.

Yvan Vandenplas*UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium †Unit of Pediatric Gastroenterology, University Hospital Ibn Rochd, Faculty of Medicine, University Hassan 2, Casablanca, Morocco ‡GI Unit, Robert Debre Hospital, Paris, France §Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands ||Gastroentérologie, Hépatologie et Nutrition, Clinique Universitaire de Pédiatrie, Grenoble Cedex 9, France ¶Pediatric Gastroenterology Hepatology and Nutrition, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey #Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia **Department of Child Health University of Indonesia, Jakarta, Indonesia ††Department of Pediatrics, Section of Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires, Argentina ‡‡Nutricia Research, Utrecht, The Netherlands §§Pediatric GI, Hepatology, and Nutrition, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates ||||Division of Pediatric Gastroenterology, Paulista School of Medicine, Federal University of São Paulo, Brazil ¶¶Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand ##Clinica Pediatrica, Università dell'Insubria, Varese, Italy ***Schneider Children's Medical Centre of Israel, Tel-Aviv University, Israel †††Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy ‡‡‡Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland §§§Gastroenterology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London, UK.
Abdelhak Abkari
Marc Bellaiche
Marc Benninga
Jean Pierre Chouraqui
FügenÇullu Çokura
Tracy Harb
Badriul Hegar
Carlos Lifschitz
Thomas Ludwig
Mohamed Miqdady
Mauro Batista de Morais
Seksit Osatakul
Silvia Salvatore
Raanan Shamir
Annamaria Staiano
Hania Szajewska
Nikhil Thapar
Hôpital Robert-Debré · FRVrije Universiteit Brussel · BECentre Hospitalier Universitaire de Grenoble · FRCentre Hospitalier Universitaire Ibn Rochd · MAChildren's Medical Research Institute · AUEmma Kinderziekenhuis · NLGreat Ormond Street Hospital · GBHospital Italiano de Buenos Aires · ARIstanbul University · TRMedical University of Warsaw · PLPrince of Songkla University · THShaikh Khalifa Medical City · AEUniversidade Federal de São Paulo · BRUniversity of Indonesia · IDUniversity of Naples Federico II · ITUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of the study was to review published evidence and the opinion of practising clinicians on the prevalence and long-term health consequences of functional gastrointestinal symptoms in infants younger than 12 months.

methodsPubMed was searched from inception to November 2014 to find articles reporting the prevalence and long-term health outcomes of infantile colic, regurgitation, functional constipation, functional diarrhoea, and dyschezia in infants younger than <12 months. A questionnaire was sent to practising clinicians worldwide, and a group of 15 international experts met to discuss the likely frequency and longer-term consequences of these symptoms.

resultsThe literature search identified 30 studies reporting the prevalence of infantile colic (2%-73%), 13 that of regurgitation (3%-87%), 8 that of functional constipation (0.05%-39.3%), 2 that of functional diarrhoea (2%-4.1%), and 3 that of dyschezia (0.9%-5.6%). The studies varied in design, populations investigated, and definition of the symptoms. Questionnaires were received from 369 respondents. The experts agreed that the likely prevalences for colic, regurgitation, and functional constipation were 20%, 30%, and 15%, respectively. The limited data in the literature for functional diarrhoea and dyschezia suggest prevalences <10%. Infantile colic may be associated with future health problems in a subset of infants.

conclusionsFunctional gastrointestinal symptoms appear to occur in a significant proportion of infants younger than 12 months and may have an impact on future health outcomes. Prospective collection of data according to agreed criteria is needed to obtain more accurate estimates of the prevalence and consequences of these symptoms.

Indexed as

Child HealthColicConstipationDiarrheaHumansInfantInfant, NewbornPrevalence

Identifiers

PMID26308317
PMCPMC4631121
OpenAlexW1153700157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.