ArticleMagnetic resonance in medicine2016
Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional iron overload assessment? A clinical evaluation at 1.5T and 3T.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 28 citations in OpenAlex.
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- Evaluation of Hepatic Iron Overload Using a Contemporary 0.55 T MRI System.Journal of magnetic resonance imaging : JMRI · 2022Article
- Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated RJournal of magnetic resonance imaging : JMRI · 2022Article
- Quantification of pancreatic iron overload and fat infiltration and their correlation with glucose disturbance in pediatric thalassemia major patients.Quantitative imaging in medicine and surgery · 2021Article
- Evaluation of liver iron overload with R2* relaxometry with versus without fat suppression: both are clinically accurate but there are differences.European radiology · 2020Article
- Article
- Autoregressive moving average modeling for hepatic iron quantification in the presence of fat.Journal of magnetic resonance imaging : JMRI · 2019Article
- Ultrashort echo time imaging for quantification of hepatic iron overload: Comparison of acquisition and fitting methods via simulations, phantoms, and in vivo data.Journal of magnetic resonance imaging : JMRI · 2019Article
- Quantitative susceptibility mapping (QSM) minimizes interference from cellular pathology in R2* estimation of liver iron concentration.Journal of magnetic resonance imaging : JMRI · 2018Article
- Quantitative susceptibility mapping in combination with water-fat separation for simultaneous liver iron and fat fraction quantification.European radiology · 2018Article
- Automated vessel exclusion technique for quantitative assessment of hepatic iron overload by R2*-MRI.Journal of magnetic resonance imaging : JMRI · 2018Article
- Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla.Magnetic resonance in medicine · 2017Article
- Radial Ultrashort TE Imaging Removes the Need for Breath-Holding in Hepatic Iron Overload Quantification by R2* MRI.AJR. American journal of roentgenology · 2017Article
- Can multi-slice or navigator-gated R2* MRI replace single-slice breath-hold acquisition for hepatic iron quantification?Pediatric radiology · 2017Article
- Comparison of clinical MRI liver iron content measurements using signal intensity ratios, RAbdominal radiology (New York) · 2016Article
- Magnetic Resonanance Imaging of the Liver (Including Biliary Contrast Agents)-Part 2: Protocols for Liver Magnetic Resonanance Imaging and Characterization of Common Focal Liver Lesions.Seminars in roentgenology · 2016Review
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7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeFat suppression (FS) via chemically selective saturation (CHESS) eliminates fat-water oscillations in multiecho gradient echo (mGRE) R2*-MRI. However, for increasing R2* values as seen with increasing liver iron content (LIC), the water signal spectrally overlaps with the CHESS band, which may alter R2*. We investigated the effect of CHESS on R2* and developed a heuristic correction for the observed CHESS-induced R2* changes.
methodsEighty patients [female, n = 49; male, n = 31; mean age (± standard deviation), 18.3 ± 11.7 y] with iron overload were scanned with a non-FS and a CHESS-FS mGRE sequence at 1.5T and 3T. Mean liver R2* values were evaluated using three published fitting approaches. Measured and model-corrected R2* values were compared and statistically analyzed.
resultsAt 1.5T, CHESS led to a systematic R2* reduction (P < 0.001 for all fitting algorithms) especially toward higher R2*. Our model described the observed changes well and reduced the CHESS-induced R2* bias after correction (linear regression slopes: 1.032/0.927/0.981). No CHESS-induced R2* reductions were found at 3T.
conclusionThe CHESS-induced R2* bias at 1.5T needs to be considered when applying R2*-LIC biopsy calibrations for clinical LIC assessment, which were established without FS at 1.5T. The proposed model corrects the R2* bias and could therefore improve clinical iron overload assessment based on linear R2*-LIC calibrations. Magn Reson Med 76:591-601, 2016. © 2015 Wiley Periodicals, Inc.
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