ArticlePloS one2015
Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of long-term almond consumption on markers for vascular function and cardiometabolic risk in men and women with prediabetes: results of a randomized, controlled cross-over trial.European journal of nutrition · 2024Trial
- Insulin resistance, aging biology, and non- communicable chronic diseases: a narrative review of bidirectional mechanisms and translational implications.Frontiers in endocrinology · 2026Review
- Short leukocyte telomere length and high plasma phospholipid fatty acids increase the risk of type 2 diabetes.Endocrine connections · 2024Article
- The effect of prognostic nutritional index on diabetic patients with myocardial infarction.Diabetology & metabolic syndrome · 2024Article
- HOMA-IR is positively correlated with biological age and advanced aging in the US adult population.European journal of medical research · 2023Article
- Vascular Aging: Assessment and Intervention.Clinical interventions in aging · 2023Review
- Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity.Current genetic medicine reports · 2022Article
- Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey.Frontiers in endocrinology · 2022Article
- Insulin Resistance and Biological Aging: The Role of Body Mass, Waist Circumference, and Inflammation.BioMed research international · 2022Article
- Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216.Frontiers in physiology · 2021Review
- Molecular basis of ageing in chronic metabolic diseases.Journal of endocrinological investigation · 2020Review
- Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization.European heart journal · 2020Article
- Telomere Length and Vascular Phenotypes in a Population-Based Cohort of Children and Midlife Adults.Journal of the American Heart Association · 2019Article
- Review
- Article
- Article
- Article
- DNA Damage: A Main Determinant of Vascular Aging.International journal of molecular sciences · 2016Review
- Diabetes Mellitus, Arterial Wall, and Cardiovascular Risk Assessment.International journal of environmental research and public health · 2016Review
- "Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes.Oxidative medicine and cellular longevity · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).
methodsThe study group included 303 subjects, mean age 51.8 ±13.3 years, free of known cardiovascular diseases and regular drug consumption. For each patient, blood pressure was measured, blood samples were available for biochemical parameters, and LTL was analyzed by real time q PCR. C-f PWV was measured with the help of SphygmoCor. SAS 9.1 was used for statistical analysis.
resultsThrough multiple linear regression analysis, c-f PWV is independently and positively associated with age (p = 0.0001) and the homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.0001) and independently negatively associated with LTL (p = 0.0378). HOMA-IR seems to have a stronger influence than SBP on arterial stiffness. In all subjects, age, HOMA-IR, LTL, and SBP predicted 32% of the variance in c-f PWV. LTL was inversely associated with HOMA-IR (p = 0.0001) and age (p = 0.0001). In all subjects, HOMA-IR, age, sex, and SBP predicted 16% of the variance in LTL.
conclusionsThese data suggest that IR is associated with cell senescence and arterial aging and could, therefore, become the main target in preventing accelerated arterial aging, besides blood pressure control. Research in telomere biology may reveal new ways of estimating cardiovascular aging and risk.
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