ArticlePloS one2015
Lack of Dietary Polyunsaturated Fatty Acids Causes Synapse Dysfunction in the Drosophila Visual System.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Dietary unsaturated fatty acids distinctly associate with the early age sleep-wake cycle and gut integrity in aged fruit flies, Drosophila melanogaster.Biogerontology · 2026Article
- Chemosensory protein 3 is a brain host factor for the induction of enhanced-locomotory activity in the BmNPV-silkworm infection model.PLoS pathogens · 2025Article
- Can the Supplementation Diet With Caryocar villosum (Aubl.) Pers Extracts Influence the Behavioral and Metabolic Parameters of Drosophila melanogaster?Archives of insect biochemistry and physiology · 2025Article
- The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster.Scientific reports · 2025Article
- Essential and nonessential fatty acid composition and use in overwintering monarch butterflies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Chemical Characterization and Beneficial Effects of Walnut Oil on aMolecules (Basel, Switzerland) · 2024Article
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- Lipidome Unsaturation Affects the Morphology and Proteome of theJournal of proteome research · 2024Article
- Modulatory actions ofFrontiers in cellular and infection microbiology · 2024Article
- Bioproduction of n-3 polyunsaturated fatty acids by nematode fatty acid desaturases and elongase in Drosophila melanogaster.Transgenic research · 2023Article
- Parasitic nematode secreted phospholipase AFrontiers in immunology · 2023Article
- Endocannabinoids produced in photoreceptor cells in response to light activateScience signaling · 2022Article
- Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders.Nutrients · 2021Review
- Functional expression of Δ12 fatty acid desaturase modulates thermoregulatory behaviour in Drosophila.Scientific reports · 2020Article
- Long-chain Omega-3 Polyunsaturated Fatty Acids in Natural Ecosystems and the Human Diet: Assumptions and Challenges.Biomolecules · 2019Review
- Different mechanisms for selective transport of fatty acids using a single class of lipoprotein inJournal of lipid research · 2019Article
- Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway.PLoS genetics · 2018Article
- Fatty acid composition of odonate's eyes.Doklady. Biochemistry and biophysics · 2017Article
- Membrane flexibility, free fatty acids, and the onset of vascular and neurological lesions in type 2 diabetes.Journal of diabetes and metabolic disorders · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acids (PUFAs) are essential nutrients for animals and necessary for the normal functioning of the nervous system. A lack of PUFAs can result from the consumption of a deficient diet or genetic factors, which impact PUFA uptake and metabolism. Both can cause synaptic dysfunction, which is associated with numerous disorders. However, there is a knowledge gap linking these neuronal dysfunctions and their underlying molecular mechanisms. Because of its genetic manipulability and its easy, fast, and cheap breeding, Drosophila melanogaster has emerged as an excellent model organism for genetic screens, helping to identify the genetic bases of such events. As a first step towards the understanding of PUFA implications in Drosophila synaptic physiology we designed a breeding medium containing only very low amounts of PUFAs. We then used the fly's visual system, a well-established model for studying signal transmission and neurological disorders, to measure the effects of a PUFA deficiency on synaptic function. Using both visual performance and eye electrophysiology, we found that PUFA deficiency strongly affected synaptic transmission in the fly's visual system. These defects were rescued by diets containing omega-3 or omega-6 PUFAs alone or in combination. In summary, manipulating PUFA contents in the fly's diet was powerful to investigate the role of these nutrients on the fly´s visual synaptic function. This study aims at showing how the first visual synapse of Drosophila can serve as a simple model to study the effects of PUFAs on synapse function. A similar approach could be further used to screen for genetic factors underlying the molecular mechanisms of synaptic dysfunctions associated with altered PUFA levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.