ArticleProceedings of the National Academy of Sciences of the United States of America2015
Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 80 citations in OpenAlex.
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- Salmonella Genomic Island 1 requires a self-encoded small RNA for mobilization.Molecular microbiology · 2021Article
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- Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits.ACS synthetic biology · 2021Article
- Small RNA-driven feed-forward loop: fine-tuning of protein synthesis through sRNA-mediated crosstalk.The European physical journal. E, Soft matter · 2021Article
- Transcriptional and Post-transcriptional Control of the Nitrate Respiration in Bacteria.Frontiers in molecular biosciences · 2021Review
- RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae.Nature communications · 2020Article
- Envelope Stress and Regulation of theJournal of bacteriology · 2020Article
- Article
- The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica.PLoS genetics · 2020Article
- Switching fatty acid metabolism by an RNA-controlled feed forward loop.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The power of cooperation: Experimental and computational approaches in the functional characterization of bacterial sRNAs.Molecular microbiology · 2020Review
- Feedback regulation of small RNA processing by the cleavage product.RNA biology · 2019Article
- Three autoinducer molecules act in concert to control virulence gene expression in Vibrio cholerae.Nucleic acids research · 2019Article
- Putative small RNAs controlling detoxification of industrial cyanide-containing wastewaters by Pseudomonas pseudoalcaligenes CECT5344.PloS one · 2019Article
- Fluorogenic RNA Aptamers: A Nano-platform for Fabrication of Simple and Combinatorial Logic Gates.Nanomaterials (Basel, Switzerland) · 2018Article
- Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E.Molecular cell · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria. Although several host transcription factors are known to regulate plasmid-borne transfer genes, RNA-based regulatory circuits for host-plasmid communication remain unknown. We describe a posttranscriptional mechanism whereby the Hfq-dependent small RNA, RprA, inhibits transfer of pSLT, the virulence plasmid of Salmonella enterica. RprA employs two separate seed-pairing domains to activate the mRNAs of both the sigma-factor σ(S) and the RicI protein, a previously uncharacterized membrane protein here shown to inhibit conjugation. Transcription of ricI requires σ(S) and, together, RprA and σ(S) orchestrate a coherent feedforward loop with AND-gate logic to tightly control the activation of RicI synthesis. RicI interacts with the conjugation apparatus protein TraV and limits plasmid transfer under membrane-damaging conditions. To our knowledge, this study reports the first small RNA-controlled feedforward loop relying on posttranscriptional activation of two independent targets and an unexpected role of the conserved RprA small RNA in controlling extrachromosomal DNA transfer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.