ArticleMolecular plant pathology2016
SCR96, a small cysteine-rich secretory protein of Phytophthora cactorum, can trigger cell death in the Solanaceae and is important for pathogenicity and oxidative stress tolerance.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
- Genome-Wide Identification of CRK Family Members in Solanaceae Crops and Functional Characterization ofCurrent issues in molecular biology · 2026Article
- A new method for Phytophthora cactorum culturing using host plant materials to prepare agar medium.Scientific reports · 2025Article
- Protoplast Transformation of Phytophthora spp.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Heterogeneity in establishment of polyethylene glycol-mediated plasmid transformations for five forest pathogenic Phytophthora species.PloS one · 2024Article
- Transcriptomic analysis reveals pathogenicity mechanisms ofFrontiers in microbiology · 2024Article
- Transcriptome analysis ofFrontiers in plant science · 2024Article
- The devastating oomycete phytopathogen Phytophthora cactorum: Insights into its biology and molecular features.Molecular plant pathology · 2023Review
- TheInternational journal of molecular sciences · 2023Article
- Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic OomycetePlants (Basel, Switzerland) · 2023Article
- Article
- Genome analysis ofFrontiers in microbiology · 2023Article
- Genome-wide identification of cysteine-rich receptor-like kinases in sweet cherry reveals that PaCRK1 enhances sweet cherry resistance to salt stress.Plant cell reports · 2022Article
- Unraveling Plant Cell Death duringMicroorganisms · 2022Review
- Plant immunity inducers: from discovery to agricultural application.Stress biology · 2022Review
- Insights of theJournal of fungi (Basel, Switzerland) · 2021Article
- Review
- A Novel, Small Cysteine-Rich Effector, RsSCR10 inFrontiers in microbiology · 2021Article
- Phytopathogenic oomycetes: a review focusing on Phytophthora cinnamomi and biotechnological approaches.Molecular biology reports · 2020Review
- Devastating intimacy: the cell biology of plant-Phytophthora interactions.The New phytologist · 2020Review
- Article
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7 authors.
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Abstract
Peptides and small molecules produced by both the plant pathogen Phytophthora and host plants in the apoplastic space mediate the relationship between the interplaying organisms. Various Phytophthora apoplastic effectors, including small cysteine-rich (SCR) secretory proteins, have been identified, but their roles during interaction remain to be determined. Here, we identified an SCR effector encoded by scr96, one of three novel genes encoding SCR proteins in P. cactorum with similarity to the P. cactorum phytotoxic protein PcF. Together with the other two genes, scr96 was transcriptionally induced throughout the developmental and infection stages of the pathogen. These genes triggered plant cell death (PCD) in the Solanaceae, including Nicotiana benthamiana and tomato. The scr96 gene did not show single nucleotide polymorphisms in a collection of P. cactorum isolates from different countries and host plants, suggesting that its role is essential and non-redundant during infection. Homologues of SCR96 were identified only in oomycetes, but not in fungi and other organisms. A stable protoplast transformation protocol was adapted for P. cactorum using green fluorescent protein as a marker. The silencing of scr96 in P. cactorum caused gene-silenced transformants to lose their pathogenicity on host plants and these transformants were significantly more sensitive to oxidative stress. Transient expression of scr96 partially recovered the virulence of gene-silenced transformants on plants. Overall, our results indicate that the P. cactorum scr96 gene encodes an important virulence factor that not only causes PCD in host plants, but is also important for pathogenicity and oxidative stress tolerance.
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