ReviewApplied microbiology and biotechnology2015
Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens.
Review in Applied microbiology and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- The Roadmap of Plant Antimicrobial Peptides Under Environmental Stress: From Farm to Bedside.Probiotics and antimicrobial proteins · 2024Review
- Review
- Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress.Journal of molecular histology · 2024Review
- Potential of Antimicrobial Peptide-OverexpressedInsects · 2022Article
- Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action.International journal of molecular sciences · 2022Review
- Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance.Royal Society open science · 2022Article
- Review
- Antagonistic Activity of Antimicrobial Metabolites Produced from Seaweed-Associated Bacillus amyloliquefaciens MTCC 10456 Against Malassezia spp.Probiotics and antimicrobial proteins · 2021Article
- Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation.Molecules (Basel, Switzerland) · 2021Article
- Anti-Staphylococcal and cytotoxic activities of the short anti-microbial peptide PVP.World journal of microbiology & biotechnology · 2020Article
- Frog Skin-Derived Peptides AgainstAntibiotics (Basel, Switzerland) · 2020Article
- Bioactive Compounds fromBiomolecules · 2020Review
- Proline-Rich Antimicrobial Peptides in Medicinal Maggots ofFrontiers in pharmacology · 2020Article
- Anti-Aging Potential of Substance P-Based Hydrogel for Human Skin Longevity.International journal of molecular sciences · 2019Article
- Bioactive Peptides Against Fungal Biofilms.Frontiers in microbiology · 2019Review
- High-level heterologous production and Functional Secretion by recombinant Pichia pastoris of the shortest proline-rich antibacterial honeybee peptide Apidaecin.Scientific reports · 2017Article
- The selective antifungal activity of Drosophila melanogaster metchnikowin reflects the species-dependent inhibition of succinate-coenzyme Q reductase.Scientific reports · 2017Article
- Article
- Insect antimicrobial peptides: potential tools for the prevention of skin cancer.Applied microbiology and biotechnology · 2016Review
- Characterization and regulation of expression of an antifungal peptide from hemolymph of an insect, Manduca sexta.Developmental and comparative immunology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs) are components of the innate immune system in many species of animals. Their diverse spectrum of activity against microbial pathogens, both as innate defense molecules and immunomodulators, makes them attractive candidates for the development of a new generation of antibiotics. Although the potential immunogenicity of AMPs means they are not suitable for injection and their susceptibility to digestive peptidases is likely to reduce their oral efficacy, they are ideal for topical formulations such as lotions, creams, shampoos, and wound dressings and could therefore be valuable products for the cosmetic industry. In this context, short AMPs (<20 amino acids) lacking disulfide bonds combine optimal antimicrobial activity with inexpensive chemical synthesis and are therefore more compatible with large-scale production and the modifications required to ensure stability, low toxicity, and microbial specificity. Proof-of-concept for the application of AMPs as novel anti-infectives has already been provided in clinical trials. This perspective considers the anti-infective properties of short AMPs lacking disulfide bonds, which are active against dermatologically important microflora. We consider the challenges that need to be addressed to facilitate the prophylactic application of AMPs in personal care products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.