ArticleThe Plant cell2015
Chlamydomonas Genome Resource for Laboratory Strains Reveals a Mosaic of Sequence Variation, Identifies True Strain Histories, and Enables Strain-Specific Studies.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 105 citations in OpenAlex.
- The cold case of state transition 7 (stt7) mutants of Chlamydomonas reinhardtii, solved by whole-genome sequencing.The New phytologist · 2026Article
- Field strains of the unicellular alga Chlamydomonas reinhardtii exhibit multicellular characteristics that shape their interactions.The ISME journal · 2026Article
- Hidden diversity: Transcriptomic and photosynthetic variation among common 'wild type' Chlamydomonas strains.The Plant journal : for cell and molecular biology · 2025Article
- Preparation, maintenance and propagation of synchronous cultures of photoactive Chlamydomonas cells.Nature protocols · 2025Review
- Genetic Predisposition Toward Multicellularity in Chlamydomonas reinhardtii.Genome biology and evolution · 2025Article
- Genome editing in the green alga Chlamydomonas: past, present practice and future prospects.The Plant journal : for cell and molecular biology · 2025Review
- Article
- An automated high-throughput lighting system for screening photosynthetic microorganisms in plate-based formats.Communications biology · 2025Article
- Article
- Periplasmic carbonic anhydrase CAH1 contributes to high inorganic carbon affinity in Chlamydomonas reinhardtii.Plant physiology · 2024Article
- The stromal side of the cytochrome b6f complex regulates state transitions.The Plant cell · 2024Article
- Scarcity of fixed carbon transfer in a model microbial phototroph-heterotroph interaction.The ISME journal · 2024Article
- Telomerase-independent survival leads to a mosaic of complex subtelomere rearrangements inGenome research · 2023Article
- Palmelloid Formation and Cell Aggregation Are Essential Mechanisms for High Light Tolerance in a Natural Strain ofInternational journal of molecular sciences · 2023Article
- The Chlamydomonas Genome Project, version 6: Reference assemblies for mating-type plus and minus strains reveal extensive structural mutation in the laboratory.The Plant cell · 2023Article
- State transition is quiet around pyrenoid and LHCII phosphorylation is not essential for thylakoid deformation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Transcriptional regulation of photoprotection in dark-to-light transition-More than just a matter of excess light energy.Science advances · 2022Article
- The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution.PLoS genetics · 2022Article
- Comparative Phenotyping of Two Commonly UsedPlants (Basel, Switzerland) · 2022Article
- The short flagella 1 (SHF1) gene inMolecular biology of the cell · 2022Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Chlamydomonas reinhardtii is a widely used reference organism in studies of photosynthesis, cilia, and biofuels. Most research in this field uses a few dozen standard laboratory strains that are reported to share a common ancestry, but exhibit substantial phenotypic differences. In order to facilitate ongoing Chlamydomonas research and explain the phenotypic variation, we mapped the genetic diversity within these strains using whole-genome resequencing. We identified 524,640 single nucleotide variants and 4812 structural variants among 39 commonly used laboratory strains. Nearly all (98.2%) of the total observed genetic diversity was attributable to the presence of two, previously unrecognized, alternate haplotypes that are distributed in a mosaic pattern among the extant laboratory strains. We propose that these two haplotypes are the remnants of an ancestral cross between two strains with ∼2% relative divergence. These haplotype patterns create a fingerprint for each strain that facilitates the positive identification of that strain and reveals its relatedness to other strains. The presence of these alternate haplotype regions affects phenotype scoring and gene expression measurements. Here, we present a rich set of genetic differences as a community resource to allow researchers to more accurately conduct and interpret their experiments with Chlamydomonas.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.