ArticleHuman immunology2015
Association of HLA-DRB1 genetic variants with the persistence of atopic dermatitis.
Article in Human immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of atopic dermatitis with an increased risk of systemic lupus erythematosus: A systematic review and meta-analysis.Journal of postgraduate medicinePooled it
- Calcineurin Inhibitors in Atopic Dermatitis: Balancing Tradition with Emerging Therapeutics.Medical sciences (Basel, Switzerland) · 2026Review
- A multidimensional analysis of prognostic factors in atopic dermatitis.Frontiers in medicine · 2025Review
- Human leukocyte antigen system associations in Malassezia-related skin diseases.Archives of dermatological research · 2023Article
- Asthma and atopic dermatitis as risk factors for rheumatoid arthritis: a bidirectional mendelian randomization study.BMC medical genomics · 2023Article
- A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis.Frontiers in genetics · 2023Article
- KIR Allelic Variation and the Remission of Atopic Dermatitis Over Time.ImmunoHorizons · 2023Article
- Human leukocyte antigen class-I variation is associated with atopic dermatitis: A case-control study.Human immunology · 2021Article
- HLA Class I Polymorphisms Influencing Both Peptide Binding and KIR Interactions Are Associated with Remission among Children with Atopic Dermatitis: A Longitudinal Study.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis.The Journal of investigative dermatology · 2021Review
- Predictive in silico binding algorithms reveal HLA specificities and autoallergen peptides associated with atopic dermatitis.Archives of dermatological research · 2020Article
- Association of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis.PloS one · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Atopic dermatitis (AD) is a waxing and waning illness of childhood that is likely caused by interactions between an altered skin barrier and immune dysregulation. The goal of our study was to evaluate the association of DRB1 genetic variants and the persistence of AD using whole exome sequencing and high resolution typing. DRB1 was interrogated based on previous reports that utilized high throughput techniques. We evaluated an ongoing nation-wide long-term cohort of children with AD in which patients are asked every 6months about their medication use and their AD symptoms. In total, 87 African-American and 50 European-American children were evaluated. Genetic association analysis was performed using a software tool focusing on amino acid variable positions shared by HLA-DRB1 alleles covering the antigen presenting domain. Amino acid variations at position 9 (pocket 9), position 26, and position 78 (pocket 4) were marginally associated with the prevalence of AD. However, the odds ratio was 0.30 (0.14, 0.68; p=0.003) for residue 78, 0.27 (0.10, 0.69; p=0.006) for residue 26 and not significant for residue 9 with respect to the persistence of AD. In conclusion, amino acid variations at peptide-binding pockets of HLA-DRB1 were associated with the persistence of AD in African-American children.
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