ArticlemBio2015
Discovery of a Novel Hepatovirus (Phopivirus of Seals) Related to Human Hepatitis A Virus.
Article in mBio, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice.PLoS pathogens · 2026Article
- Review
- The hepatocyte traffic network in the human hepatitis A virus biological cycle from an evolutionary perspective.Communications biology · 2025Article
- Hepatovirus infections in juvenile seals from the North Sea.Npj viruses · 2025Article
- Senecavirus cetus a novel picornavirus isolated from cetaceans represents a major host switching to the marine environment.Npj viruses · 2024Article
- Identification and Genomic Characterization of Two Novel Hepatoviruses in Shrews from Yunnan Province, China.Viruses · 2024Article
- Genomic characterization of a novel Hepatovirus identified in Maranhão state, Brazil.Scientific reports · 2024Article
- Viral metagenomic survey of Caspian seals.Frontiers in veterinary science · 2024Article
- Identification and characterization of multiple novel picornaviruses in fecal samples of bar-headed goose.Frontiers in microbiology · 2024Article
- Divergent Genotype of Hepatitis A Virus in Alpacas, Bolivia, 2019.Emerging infectious diseases · 2023Article
- Hepatitis A virus infection.Nature reviews. Disease primers · 2023Review
- Cell entry and release of quasi-enveloped human hepatitis viruses.Nature reviews. Microbiology · 2023Review
- Novel viral and microbial species in a translocated Toutouwai (Petroica longipes) population from Aotearoa/New Zealand.One health outlook · 2022Article
- Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.PLoS pathogens · 2022Article
- Pathogenicity and virulence of hepatitis A virus.Virulence · 2021Review
- Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases.mBio · 2021Article
- Editorial: Origin and Evolution of Hepatitis Viruses.Frontiers in microbiology · 2021Article
- Genomic Characterization of Picornaviruses Isolated From Ribbon (Frontiers in veterinary science · 2020Article
- The Critical Role of Codon Composition on the Translation Efficiency Robustness of the Hepatitis A Virus Capsid.Genome biology and evolution · 2019Article
- Evolutionary biology of human hepatitis viruses.Journal of hepatology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
unlabelledDescribing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE: Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.