ArticleJournal of clinical hypertension (Greenwich, Conn.)2016
Management of Hypertensive Patients With Multiple Drug Intolerances: A Single-Center Experience of a Novel Treatment Algorithm.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multiple drug-intolerant hypertension: a case series utilising a novel-treatment algorithm.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016Pooled it
- Multiple Drug Intolerance Syndrome and Arterial Hypertension-Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Characterization, epidemiology and risk factors of multiple drug allergy syndrome and multiple drug intolerance syndrome: A systematic review.Clinical and translational allergy · 2022Article
- Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity.Current clinical pharmacology · 2019Review
- Novel stratified medicines approach to manage uncontrolled hypertension due to multiple drug intolerances.BMJ case reports · 2018Article
- Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result.Medicine · 2017Article
- Multidrug intolerance in the treatment of hypertension: result from an audit of a specialized hypertension service.Therapeutic advances in drug safety · 2017Article
- Renal denervation in hypertensive patients not on blood pressure lowering drugs.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Central iliac arteriovenous anastomosis for hypertension: targeting mechanical aspects of the circulation.Current hypertension reports · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple drug intolerance to antihypertensive medications (MDI-HTN) is an overlooked cause of nonadherence. In this study, 55 patients with MDI-HTN were managed with a novel treatment algorithm utilizing sequentially initiated monotherapies or combinations of maximally tolerated doses of fractional tablet doses, liquid formulations, transdermal preparations, and off-label tablet medications. A total of 10% of referred patients had MDI-HTN, resulting in insufficient pharmacotherapy and baseline office blood pressure (OBP) of 178±24/94±15 mm Hg. At baseline, patients were intolerant to 7.6±3.6 antihypertensives; they were receiving 1.4±1.1 medications. After 6 months on the novel MDI-HTN treatment algorithm, both OBP and home blood pressure (HBP) were significantly reduced, with patients receiving 2.0±1.2 medications. At 12 months, OBP was reduced from baseline by 17±5/9±3 mm Hg (P<.01, P<.05) and HBP was reduced by 11±5/12±3 mm Hg (P<.01 for both) while patients were receiving 1.9±1.1 medications. Application of a stratified medicine approach allowed patients to tolerate increased numbers of medications and achieved significant long-term lowering of blood pressure.
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