Evidence map›Paper›PMID 26306727›Full record

ArticleEndocrine connections2015

Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users.

Eric M Ndombi, Valentine Budambula, Mark K Webale, Francis O Musumba, Jesca O Wesongah, Erick Mibei, Aabid A Ahmed, Raphael Lihana, Tom Were

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine connections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Functional Haplotypes in theEthiopian journal of health sciences · 2020
    Article
  7. Hepatic steatosis in HCV-infected persons in the direct-acting antiviral era.Tropical diseases, travel medicine and vaccines · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Eric M NdombiBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Valentine BudambulaBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Mark K WebaleBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Francis O MusumbaBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Jesca O WesongahBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Erick MibeiBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Aabid A AhmedBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Raphael LihanaBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya.
Tom WereBomu HospitalMombasa, KenyaDepartment of PathologyKenyatta University, Nairobi, KenyaDepartment of Environment and Health SciencesTechnical University of Mombasa, Mombasa, KenyaDepartment of Biomedical Sciences and TechnologyMaseno University, Maseno, KenyaDepartment of Medical Laboratory SciencesJomo Kenyatta University of Agriculture and Technology, Juja, KenyaKapkatet CampusUniversity of Kabianga, Kericho, KenyaCentre for Virus ResearchKenya Medical Research Institute, Nairobi, KenyaDepartment of Medical Laboratory SciencesMasinde Muliro University of Science and Technology, Post Box 190-50100 Kakamega, Kenya mugogwe@yahoo.com.
Maseno University · KEUniversity of Kabianga · KEJomo Kenyatta University of Agriculture and Technology · KEKenya Medical Research Institute · KEKenyatta University · KETechnical University of Mombasa · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (P<0.0001). Post-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (P<0.05) and healthy controls (P<0.05). However, adiponectin levels were elevated in HCV mono-infected IDUs relative to HIV mono-infected ART-naive (P<0.001) and -experienced (P<0.001) as well as HIV and HCV co-infected ART-naive (P<0.05) IDUs. Furthermore, adiponectin correlated with weight (ρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=-0.626; P<0.0001), hip (ρ=-0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=-0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs.

Indexed as

adiponectinanthropometric markers of adiposityanti-retroviral treatmenthepatitis C virusHIVinjection drug users

Identifiers

PMID26306727
PMCPMC4566843
OpenAlexW2108625703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.