Evidence map›Paper›PMID 26306690›Full record

ArticleJournal of neurovirology2016

Subtype associations with HIV-associated neurocognitive disorder in China.

Tyler R C Day, Davey M Smith, Robert K Heaton, Donald Franklin, Myers W Tilghman, Scott Letendre, Hua Jin, Zunyou Wu, Chuan Shi, Xin Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tyler R C DayUniversity of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA. tyler.day@outlook.com.
Davey M SmithUniversity of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.
Robert K HeatonVeterans Administration San Diego Healthcare System, San Diego, CA, USA.
Donald FranklinVeterans Administration San Diego Healthcare System, San Diego, CA, USA.
Myers W TilghmanVeterans Administration San Diego Healthcare System, San Diego, CA, USA.
Scott LetendreUniversity of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.
Hua JinUniversity of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.
Zunyou WuChinese Center for Disease Control and Prevention, Beijing, China.
Chuan ShiInstitute of Mental Health, Peking University, Beijing, China.
Xin YuInstitute of Mental Health, Peking University, Beijing, China.
Josué Pérez-SantiagoUniversity of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Molecular Epidemiology for HIV Prevention for Drug Users and Other Risk Groups DP1DA034978 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$4.1M
A Multi-Site Investigation into the Effect of HIV Clade on Neurocognitive ImpairmR01MH083552 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2008 to 2012
$3.3M
Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in ChinaR01MH092225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2010 to 2014
$2.8M
Effects of Host and Viral Aging on NeurocognitionR01MH097520 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$2.0M
Mentoring Translational Research in HIVK24AI100665 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2021
$1.5M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
NIAID NIH HHS AI036214NIAID NIH HHS AI100665NIAID NIH HHS K24 AI100665NIAID NIH HHS P30 AI036214NIDA NIH HHS DA034978NIDA NIH HHS DP1 DA034978NIMH NIH HHS K24 MH097673NIMH NIH HHS MH062512NIMH NIH HHS MH083552NIMH NIH HHS MH097520NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH083552NIMH NIH HHS R01 MH092225NIMH NIH HHS R01 MH097520
6 · The paper itself

Abstract

Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p < 0.01) and CD4(+) counts (p = 0.03). HAND was also associated with AIDS (p < 0.01), but subtype was not (p = 0.198). Furthermore, worse impairment correlated with higher viral diversity (r = 0.16, p < 0.01), lower nadir (r = -0.17, p < 0.01), and CD4(+) counts (r = -0.11, p = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND.

Indexed as

GenotypeAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChinaCognitive DysfunctionCohort StudiesExecutive FunctionFemaleHIV-1HIV InfectionsHumansMaleNeuropsychological TestsPsychomotor PerformanceAnti-HIV AgentsCD4 nadirHIV-associatedHIV subtypeNeurocognitive disordersNeurocognitive impairment

Identifiers

PMID26306690
PMCPMC4769127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.