SynthesisScientific reports2015
Restrictive blood transfusion strategies and associated infection in orthopedic patients: a meta-analysis of 8 randomized controlled trials.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Restrictive versus Liberal blood transfusion strategies for patients undergoing orthopedic surgery: a meta-analysis of randomised trials with trial sequential analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- A systematic review and meta-analysis of the effects of tranexamic acid in surgical procedure for intracranial meningioma.Journal of neuro-oncology · 2023Pooled it
- Restrictive versus liberal strategy for red blood-cell transfusion in hip fracture patients: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Pooled it
- Postoperative autotransfusion drain after total hip arthroplasty: a meta-analysis of randomized controlled trials.Scientific reports · 2016Pooled it
- Comparison of clinical outcomes of enoxaparin and aspirin for postoperative venous thromboembolism prophylaxis in hip fractures.Acta orthopaedica et traumatologica turcica · 2026Article
- Discriminating infectious and non-infectious fever after open craniotomy: a combined statistical and machine learning approach.Neurosurgical review · 2026Article
- Preoperative Iron Isomaltoside administration enhances postoperative anemia recovery in robotic pancreatic surgery.Journal of robotic surgery · 2026Article
- Case Report: Effect of preventive intravenous iron infusion on postoperative hemoglobin levels in a female patient with latent iron deficiency anemia before total hip arthroplasty.Frontiers in medicine · 2025Article
- Tranexamic acid does not affect intraoperative blood loss or in-hospital outcomes after acetabular fracture surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- There is no dose-response relationship between allogeneic blood transfusion and healthcare-associated infection: a retrospective cohort study.Antimicrobial resistance and infection control · 2021Article
- Perioperative Use of Glucocorticoids and Intraoperative Hypotension May Affect the Incidence of Postoperative Infection in Patients with Gastric Cancer: A Retrospective Cohort Study.Cancer management and research · 2021Article
- Rethinking strategies for blood transfusion in hip fracture patients.OTA international : the open access journal of orthopaedic trauma · 2020Article
- Cell salvage within adult and pediatric idiopathic scoliosis surgery: A random cross-sectional study.SICOT-J · 2020Article
- Implementation of a patient blood management program in an Australian private hospital orthopedic unit.Journal of blood medicine · 2018Article
- Fracture-related infection in Open Long-bone Fractures: A Bicenter Case-control Study in a Limited Resource Country.JB & JS open accessArticle
- Pre-operative transfusions are associated with numerous post-operative complications in total hip arthroplasty.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study sought to evaluate whether restrictive blood transfusion strategies are associated with a risk of infection in orthopedic patients by conducting a meta-analysis of randomized controlled trials (RCTs). RCTs with restrictive versus liberal red blood cell (RBC) transfusion strategies were identified by searching Medline, Embase, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews from their inception to December 2014. Eight RCTs with infections as outcomes were included in the final analysis. According to the Jadad scale, all studies were considered to be of high quality. The pooled risk ratio [RR] for the association between transfusion strategy and infection was 0.65 (95% CI, 0.47-0.91; p = 0.012), and the number of patients needed to treat to avoid an infection using a restrictive transfusion strategy was 62. No heterogeneity was observed. The sensitivity analysis indicated unstable results, and no significant publication bias was observed. This meta-analysis of RCTs demonstrates that restrictive transfusion strategies in orthopedic patients result in a significant reduction in infections compared with more liberal strategies.
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