Evidence map›Paper›PMID 26306494›Full record

ArticleJournal of diabetes science and technology2015

Basement Membrane-Based Glucose Sensor Coatings Enhance Continuous Glucose Monitoring in Vivo.

Ulrike Klueh, Yi Qiao, Caroline Czajkowski, Izabela Ludzinska, Omar Antar, Donald L Kreutzer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Future of Automated Insulin Delivery Systems.Diabetes technology & therapeutics · 2017
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ulrike KluehCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT, USA Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT, USA klueh@uchc.edu.
Yi QiaoCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT, USA Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT, USA.
Caroline CzajkowskiCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT, USA Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT, USA.
Izabela LudzinskaCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT, USA Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT, USA.
Omar AntarCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT, USA Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT, USA.
Donald L KreutzerCenter for Molecular Tissue Engineering, University of Connecticut, School of Medicine, Farmington, CT, USA Department of Surgery, University of Connecticut, School of Medicine, Farmington, CT, USA.
University of Connecticut · US

Funding

Impact of the Vascular System and CGMDP3DK101082 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KREUTZER, DON · 2013 to 2013
$1.8M
NIDDK NIH HHS DP3 DK101082
6 · The paper itself

Abstract

backgroundImplantable glucose sensors demonstrate a rapid decline in function that is likely due to biofouling of the sensor. Previous efforts directed at overcoming this issue has generally focused on the use of synthetic polymer coatings, with little apparent effect in vivo, clearly a novel approach is required. We believe that the key to extending sensor life span in vivo is the development of biocompatible basement membrane (BM) based bio-hydrogels as coatings for glucose sensors.

methodBM based bio-hydrogel sensor coatings were developed using purified BM preparations (ie, Cultrex from Trevigen Inc). Modified Abbott sensors were coated with Cultrex BM extracts. Sensor performance was evaluated for the impact of these coatings in vitro and in vivo in a continuous glucose monitoring (CGM) mouse model. In vivo sensor function was assessed over a 28-day time period expressed as mean absolute relative difference (MARD) values. Tissue reactivity of both Cultrex coated and uncoated glucose sensors was evaluated at 7, 14, 21 and 28 days post-sensor implantation with standard histological techniques.

resultsThe data demonstrate that Cultrex-based sensor coatings had no effect on glucose sensor function in vitro. In vivo glucose sensor performance was enhanced following BM coating as determined by MARD analysis, particularly in weeks 2 and 3. In vivo studies also demonstrated that Cultrex coatings significantly decreased sensor-induced tissue reactions at the sensor implantation sites.

conclusionBasement-membrane-based sensor coatings enhance glucose sensor function in vivo, by minimizing or preventing sensor-induced tissues reactions.

Indexed as

AnimalsBiosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringHydrogelsInsulin Infusion SystemsMiceBlood GlucoseHydrogelsbasement membranebiocompatibilitycontinuous glucose monitoringextracellular matricesglucose sensor coatingsimplantable glucose sensorTrevigen

Identifiers

PMID26306494
PMCPMC4667328
OpenAlexW2177379228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.