ReviewAdvances in experimental medicine and biology2015
Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches.
Review in Advances in experimental medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03316521 (Safety, Tolerability, Pharmacokinetics), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Single Ascending Dose (SAD) and a Multiple Dose (MD) of the Complement Inhibitor AMY-101. A Prospective, Single-center, Open-label, First-In-Human (FIH) Clinical Study in Healthy Male Volunteers
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Using genetics to explore complement C5 as a druggable protein in periodontitis.Frontiers in immunology · 2024Pooled it
- Calibrated interdental brushing for the prevention of periodontal pathogens infection in young adults - a randomized controlled clinical trial.Scientific reports · 2019Trial
- Periodontal Disease and Age-Related Maculopathy: A Case Report.Clinical medicine insights. Case reports · 2025Article
- The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.CNS neuroscience & therapeutics · 2024Review
- Periodontal and microbiological data in patients with mucous membrane pemphigoid in a French population in 2021-2022: A pilot cross-sectional study.Health science reports · 2024Article
- Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis.World journal of gastroenterology · 2023Review
- Complement as a vital nexus of the pathobiological connectome for acute respiratory distress syndrome: An emerging therapeutic target.Frontiers in immunology · 2023Review
- Molecular systems architecture of host-microbiome interactions in periodontitis.JADA foundational science · 2023Review
- Impact of oral microbiota on pathophysiology of GVHD.Frontiers in immunology · 2023Review
- Increased Levels of C5a in Gingival Crevicular Fluid and Saliva of Patients with Periodontal Disease.Pathogens (Basel, Switzerland) · 2022Article
- Microbiota in health and diseases.Signal transduction and targeted therapy · 2022Review
- Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.Frontiers in immunology · 2022Article
- An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Frontiers in immunology · 2022Article
- Vascular Changes and Hypoxia in Periodontal Disease as a Link to Systemic Complications.Pathogens (Basel, Switzerland) · 2021Review
- Epigenetic changes caused by diabetes and their potential role in the development of periodontitis.Journal of diabetes investigation · 2021Article
- Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption.International journal of molecular sciences · 2021Article
- Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment.Journal of periodontal research · 2021Article
- Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis.BioMed research international · 2021Article
- Complement activation links inflammation to dental tissue regeneration.Clinical oral investigations · 2020Review
- Dental Pulp Mesenchymal Stem Cells as a Treatment for Periodontal Disease in Older Adults.Stem cells international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The complement system is a network of interacting fluid-phase and cell surface-associated molecules that trigger, amplify, and regulate immune and inflammatory signaling pathways. Dysregulation of this finely balanced network can destabilize host-microbe homeostasis and cause inflammatory tissue damage. Evidence from clinical and animal model-based studies suggests that complement is implicated in the pathogenesis of periodontitis, a polymicrobial community-induced chronic inflammatory disease that destroys the tooth-supporting tissues. This review discusses molecular mechanisms of complement involvement in the dysbiotic transformation of the periodontal microbiome and the resulting destructive inflammation, culminating in loss of periodontal bone support. These mechanistic studies have additionally identified potential therapeutic targets. In this regard, interventional studies in preclinical models have provided proof-of-concept for using complement inhibitors for the treatment of human periodontitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.