ArticleScientific reports2015
Combining microscopy with mesoscopy using optical and optoacoustic label-free modes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Integrated two-photon and optoacoustic microscopy for functional neuroimaging.Scientific reports · 2025Article
- Nanophotonic-enhanced photoacoustic imaging for brain tumor detection.Journal of nanobiotechnology · 2025Review
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Overdriven laser diode optoacoustic microscopy.Scientific reports · 2023Article
- Hybrid confocal fluorescence and photoacoustic microscopy for the label-free investigation of melanin accumulation in fish scales.Scientific reports · 2022Article
- Label-free concurrent 5-modal microscopy (Co5M) resolves unknown spatio-temporal processes in wound healing.Communications biology · 2021Article
- Recent development of near-infrared photoacoustic probes based on small-molecule organic dye.RSC chemical biology · 2021Review
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- Pushing the boundaries of optoacoustic microscopy by total impulse response characterization.Nature communications · 2020Article
- Photoacoustic Imaging Probes Based on Tetrapyrroles and Related Compounds.International journal of molecular sciences · 2020Review
- Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae.Biomedical optics express · 2020Article
- Cardiovascular optoacoustics: From mice to men - A review.Photoacoustics · 2019Review
- The integrated high-resolution reflection-mode photoacoustic and fluorescence confocal microscopy.Photoacoustics · 2019Article
- Optoacoustic mesoscopy for biomedicine.Nature biomedical engineering · 2019Review
- Integrated multimodal photoacoustic microscopy with OCT- guided dynamic focusing.Biomedical optics express · 2019Article
- Simultaneous ultra-high frequency photoacoustic microscopy and photoacoustic radiometry of zebrafish larvaePhotoacoustics · 2018Article
- Blood vessel imaging using radiofrequency-induced second harmonic acoustic response.Scientific reports · 2018Article
- Quad-mode functional and molecular photoacoustic microscopy.Scientific reports · 2018Article
- Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture.European journal of medical research · 2018Article
- Optoacoustic microscopy at multiple discrete frequencies.Light, science & applications · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biology requires observations at multiple geometrical scales, a feature that is not typically offered by a single imaging modality. We developed a hybrid optical system that not only provides different contrast modes but also offers imaging at different geometrical scales, achieving uniquely broad resolution and a 1000-fold volume sampling increase compared to volumes scanned by optical microscopy. The system combines optoacoustic mesoscopy, optoacoustic microscopy and two-photon microscopy, the latter integrating second and third harmonic generation modes. Label-free imaging of a mouse ear and zebrafish larva ex-vivo demonstrates the contrast and scale complementarity provided by the hybrid system. We showcase the superior anatomical orientation offered by the label-free capacity and hybrid operation, over fluorescence microscopy, and the dynamic selection between field of view and resolution achieved, leading to new possibilities in biological visualization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.