Evidence map›Paper›PMID 26306241›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2015

Mining Biomedical Literature to Explore Interactions between Cancer Drugs and Dietary Supplements.

Rui Zhang, Terrance J Adam, Gyorgy Simon, Michael J Cairelli, Thomas Rindflesch, Serguei Pakhomov, Genevieve B Melton

Abstract read
In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Drug repurposing for COVID-19 via knowledge graph completion.Journal of biomedical informatics · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. MeSHDD: Literature-based drug-drug similarity for drug repositioning.Journal of the American Medical Informatics Association : JAMIA · 2017
    Article
  13. Article
  14. Evaluation of Herbal and Dietary Supplement Resource Term Coverage.Studies in health technology and informatics · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rui ZhangInstitute for Health Informatics, University of Minnesota, Minneapolis, MN ; Department of Surgery, University of Minnesota, Minneapolis, MN.
Terrance J AdamInstitute for Health Informatics, University of Minnesota, Minneapolis, MN ; College of Pharmacy, University of Minnesota, Minneapolis, MN.
Gyorgy SimonInstitute for Health Informatics, University of Minnesota, Minneapolis, MN.
Michael J CairelliLister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health.
Thomas RindfleschLister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health.
Serguei PakhomovInstitute for Health Informatics, University of Minnesota, Minneapolis, MN ; College of Pharmacy, University of Minnesota, Minneapolis, MN.
Genevieve B MeltonInstitute for Health Informatics, University of Minnesota, Minneapolis, MN ; Department of Surgery, University of Minnesota, Minneapolis, MN.
National Center for Biotechnology Information · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Discovery and Visualization of New Information from Clinical Reports in the EHRR01HS022085 · AHRQ · UNIVERSITY OF MINNESOTA · PI MELTON-MEAUX, GENEVIEVE B · 2013 to 2016
$1.9M
AHRQ HHS R01 HS022085NCATS NIH HHS UL1 TR000114
6 · The paper itself

Abstract

Interactions between cancer drugs and dietary supplements are clinically important and have not been extensively investigated through mining of the biomedical literature. We report on a previously introduced method now enhanced by machine learning-based filtering. Potential interactions are extracted by using relationships in the form of semantic predications. Semantic predications stored in SemMedDB, a database of structured knowledge generated from MEDLINE, were filtered and connected by two interaction pathways to explore potential drug-supplement interactions (DSIs). The lasso regression filter was trained by using SemRep output features in an expert annotated corpus and used to rank retrieved predications by predicted precision. We found not only known interactions but also inferred several unknown potential DSIs by appropriate filtering and linking of semantic predications.

Identifiers

PMID26306241
PMCPMC4525230
OpenAlexW1194922867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.