ArticleProceedings of the National Academy of Sciences of the United States of America2015
Subset of early radial glial progenitors that contribute to the development of callosal neurons is absent from avian brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Early fate diversification of radial glial progenitors during corticogenesis.Science advances · 2026Article
- Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis.bioRxiv : the preprint server for biology · 2025Article
- Neocortical neurogenesis: a proneural gene perspective.The FEBS journal · 2025Review
- A tribute to professor Rudolf Nieuwenhuys: the grammar of neuroscience.Brain structure & function · 2025Article
- Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.Nature communications · 2024Article
- Comparison of genes involved in brain development: insights into the organization and evolution of the telencephalic pallium.Scientific reports · 2024Article
- Non-uniform temporal scaling of developmental processes in the mammalian cortex.Nature communications · 2023Article
- Cell Type-Specific Transcriptional Control of Gsk3β in the Developing Mammalian Neocortex.Frontiers in neuroscience · 2022Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- A protocol forSTAR protocols · 2021Article
- Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Ferret as a Model System for Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- Variations of telencephalic development that paved the way for neocortical evolution.Progress in neurobiology · 2020Review
- Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes.The Journal of cell biology · 2020Article
- Differential timing of a conserved transcriptional network underlies divergent cortical projection routes across mammalian brain evolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture.eLife · 2019Article
- A mathematical insight into cell labelling experiments for clonal analysis.Journal of anatomy · 2019Article
- Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.Development (Cambridge, England) · 2018Article
- Update on forebrain evolution: From neurogenesis to thermogenesis.Seminars in cell & developmental biology · 2018Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
The classical view of mammalian cortical development suggests that pyramidal neurons are generated in a temporal sequence, with all radial glial cells (RGCs) contributing to both lower and upper neocortical layers. A recent opposing proposal suggests there is a subgroup of fate-restricted RGCs in the early neocortex, which generates only upper-layer neurons. Little is known about the existence of fate restriction of homologous progenitors in other vertebrate species. We investigated the lineage of selected Emx2+ [vertebrate homeobox gene related to Drosophila empty spiracles (ems)] RGCs in mouse neocortex and chick forebrain and found evidence for both sequential and fate-restricted programs only in mouse, indicating that these complementary populations coexist in the developing mammalian but not avian brain. Among a large population of sequentially programmed RGCs in the mouse brain, a subset of self-renewing progenitors lack neurogenic potential during the earliest phase of corticogenesis. After a considerable delay, these progenitors generate callosal upper-layer neurons and glia. On the other hand, we found no homologous delayed population in any sectors of the chick forebrain. This finding suggests that neurogenic delay of selected RGCs may be unique to mammals and possibly associated with the evolution of the corpus callosum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.