SynthesisPloS one2015
The Role of Hemosiderin Excision in Seizure Outcome in Cerebral Cavernous Malformation Surgery: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- The prevalence and influencing factors of frailty in patients with chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Surgery for cerebral cavernous malformations: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Treatment of Cerebral Cavernous Malformations Presenting With Seizures: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- In Vivo Longitudinal Mapping of Brain Iron Accumulation After Pilocarpine-Induced Status Epilepticus.Molecular neurobiology · 2026Article
- Navigating the Eloquent Brain: A Multicenter Study on the Safety and Efficacy of Symptomatic Cavernoma Resection.Brain sciences · 2026Article
- Predictors of seizure as presenting symptom of cerebral cavernomas.Neurosurgical review · 2026Article
- Controversies in Cavernous Malformation Management: A Comprehensive Review of Current Literature.Journal of clinical medicine · 2025Review
- Recent novelties in research and management of cerebrospinal cavernous malformations.Acta neurochirurgica · 2024Review
- Article
- Treatment of Brain Arteriovenous Malformations.Advances and technical standards in neurosurgery · 2024Article
- Epilepsy associated with cerebral cavernous malformations managed with stereotactic radiosurgery: an international, multicenter study.Journal of neurology · 2023Article
- Modified Transanterior Perforated Substance Approach Using the Medial Territory to Thalamomesencephalic Cavernous Malformations: A Case Report.Neurosurgery practice · 2023Article
- Language improvement after awake craniotomy in a 12-year-old child: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Quality of life and mood assessment in conservatively treated cavernous malformation-related epilepsy.Brain and behavior · 2022Article
- Displacement of Gray Matter and Incidence of Seizures in Patients with Cerebral Cavernous Malformations.Biomedicines · 2021Article
- Paediatric giant cavernomas: report of three cases with a review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers.Neurobiology of disease · 2019Review
- Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population-based cohort study.British journal of clinical pharmacology · 2018Article
- Should we resect peri-lesional hemosiderin deposits when performing lesionectomy in patients with cavernoma-related epilepsy (CRE)?Neurosurgical review · 2017Review
- A predicted model for postoperative seizure outcomes after the surgical resection of supratentorial cavernous malformations.Medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeWhether the excision of hemosiderin surrounding cerebral cavernous malformations (CCMs) is necessary to achieve a seizure-free result has been the subject of debate. Here, we report a systematic review of related literature up to Jan 1, 2015 including 594 patients to assess the effect of hemosiderin excision on seizure outcome in patients with CCMs by meta-analysis.
methodsTen studies comparing extended hemosiderin excision with only lesion resection were identified by searching the English-language literature. Meta-analyses, subgroup analyses and sensitivity analysis were conducted to determine the association between hemosiderin excision and seizure outcome after surgery.
resultsSeizure outcome was significantly improved in the patients who underwent an extended excision of the surrounding hemosiderin (OR, 0.62; 95% CI: 0.42-0.91; P = 0.01). In subgroup analysis, studies from Asia (OR, 0.42; 95% CI: 0.25-0.71; P = 0.001), male-majority (female ratio < 50%) studies (OR, 0.56; 95% CI: 0.33-0.96; P = 0.04), low occurrence rate of multiple CCMs (OR, 0.37; 95% CI: 0.20-0.71; P = 0.003), cohort studies (OR, 0.44; 95% CI: 0.28-0.68; P = 0.78), longer duration of seizure symptoms (> 1 year) before surgery (OR, 0.43; 95% CI: 0.22-0.84; P = 0.01), lesion diameter > 2 cm (OR, 0.41; 95% CI: 0.19-0.87; P = 0.02) and short-term (< 3 years) follow-up (OR, 0.48; 95% CI: 0.29-0.80; P = 0.005) tended to correlate with a significantly favorable outcome.
conclusionPatients who underwent extended surrounding hemosiderin excision could exhibit significantly improved seizure outcomes compared to patients without hemosiderin excision. However, further well-designed prospective multiple-center RCT studies are still needed.
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