ArticlePloS one2015
Measurement of Local Partial Pressure of Oxygen in the Brain Tissue under Normoxia and Epilepsy with Phosphorescence Lifetime Microscopy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain.Epilepsia · 2026Article
- Tissue Oxygenation Dynamics During Seizure to Spreading Depolarization in Rat Brain.bioRxiv : the preprint server for biology · 2025Article
- Out-of-focus signal rejection forBiomedical optics express · 2025Article
- The hemodynamic initial-dip consists of both volumetric and oxymetric changes reflecting localized spiking activity.Frontiers in neuroscience · 2023Article
- Difluoroboron β-diketonate polylactic acid oxygen nanosensors for intracellular neuronal imaging.Scientific reports · 2021Article
- Skeletal muscle interstitial PoJournal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil.Magma (New York, N.Y.) · 2019Article
- Astrocytic endfoot CaJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation.NeuroImage · 2018Article
- Skeletal muscle microvascular and interstitial PO2 from rest to contractions.The Journal of physiology · 2018Article
- Spatial landscape of oxygen in and around microvasculature during epileptic events.Neurophotonics · 2017Article
- Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures.Aerospace medicine and human performance · 2016Review
- A Metabolic Paradigm for Epilepsy.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this work a method for measuring brain oxygen partial pressure with confocal phosphorescence lifetime microscopy system is reported. When used in conjunction with a dendritic phosphorescent probe, Oxyphor G4, this system enabled minimally invasive measurements of oxygen partial pressure (pO2) in cerebral tissue with high spatial and temporal resolution during 4-AP induced epileptic seizures. Investigating epileptic events, we characterized the spatio-temporal distribution of the "initial dip" in pO2 near the probe injection site and along nearby arterioles. Our results reveal a correlation between the percent change in the pO2 signal during the "initial dip" and the duration of seizure-like activity, which can help localize the epileptic focus and predict the length of seizure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.