ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2016
Evaluation of Index of Cardio-Electrophysiological Balance (iCEB) as a New Biomarker for the Identification of Patients at Increased Arrhythmic Risk.
Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706104 (Determining the Effects of Two Different Anesthesia Induction Techniques on QT Distance in Cardiac Surgery Patients With Two Different QT Measurement Techniques), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determining the Effects of Two Different Anesthesia Induction Techniques on QT Distance in Cardiac Surgery Patients With Two Different QT Measurement Techniques
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Restitution metrics in Brugada syndrome: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020Pooled it
- Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial.BMC anesthesiology · 2022Trial
- Electrophysiological Markers in Hypertrophic Cardiomyopathy: Enhancing Sudden Cardiac Death Risk Prediction with Index of Cardiac Electrophysiological Balance and Its Corrected Variant.Anatolian journal of cardiology · 2026Article
- Electrocardiographic Digital Biomarkers in Asymptomatic Schoolchildren with Rheumatic Heart Disease.Pediatric cardiology · 2026Article
- Ferric Carboxymaltose Therapy Improves the Index of Cardiac Electrophysiological Balance in Iron-Deficient Heart Failure with Reduced Ejection Fraction.Medicina (Kaunas, Lithuania) · 2026Article
- Electrophysiological Changes in Children with Isolated Persistent Left Superior Vena Cava: A Case-Control Study.Journal of clinical medicine · 2026Article
- Increased Corrected Index of Cardiac Electrophysiological Balance in Behçet's Disease: Association with Disease Duration.Journal of clinical medicine · 2026Article
- Electrophysiological Response in Hypertensive Crisis: An Evaluation of the ICEB Score.Medicina (Kaunas, Lithuania) · 2026Article
- The Impact of Intraoperative Position Changes on Hemodynamics and Cardiac Electrophysiological Balance Index in Patients with Severe Obesity Undergoing Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2026Observational
- The Impact of Body Mass Index and Nutritional Status on Cardiac Electrophysiological Balance Using ICEB and ICEBc: A Cross-Sectional Approach.Journal of cardiovascular development and disease · 2026Article
- Impact of two sedation protocols on cardiac electrophysiology during spinal anesthesia.Turkish journal of medical sciences · 2026Observational
- Index of cardiac electrophysiological balance in patients with vasovagal syncope confirmed by head-up tilt test.Frontiers in cardiovascular medicine · 2026Article
- Electrocardiographic markers of arrhythmogenic risk in patients with isolated coronary artery ectasia.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Machine learning for classification of advanced rheumatic heart disease using electrocardiogram in cardiology ward.BMC cardiovascular disorders · 2025Article
- Effect of Dapagliflozin Treatment on Index of Cardiac Electrophysiological Balance in Patients With Heart Failure With Reduced Ejection Fraction.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025Article
- Assessing arrhythmic risk in chronic kidney disease: A study of the index of cardiac-electrophysiological balance.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Transient ischemic attack and acute ischemic stroke: evidence of altered corrected index of cardiac electrophysiological balance.Frontiers in neurology · 2025Article
- Using the Cardiac-Electrophysiological Balance Index to Predict Arrhythmia Risk After Colonoscopy.Medicina (Kaunas, Lithuania) · 2024Article
- Effect of long-term use of antipsychotics on the ventricular repolarization index.BMC psychiatry · 2024Article
- Influence of cigarette smoking on the Index of Cardiac Electrophysiological Balance in apparently healthy Angolans.Global cardiology science & practice · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently a new risk marker for drug-induced arrhythmias called index of cardio-electrophysiological balance (iCEB), measured as QT interval divided by QRS duration, was evaluated in an animal model. It was hypothesized that iCEB is equivalent to the cardiac wavelength λ (λ = effective refractory period (ERP) x conduction velocity) and that an increased or decreased value of iCEB would potentially predict an increased susceptibility to TdP or non-TdP mediated VT/VF, respectively.
methodsFirst, the correlation between QT interval and ERP was evaluated by invasively measuring ERP during a ventricular stimulation protocol in humans (N = 40). Then the effect of administration of sotalol and flecainide on iCEB was measured in 40 patients with supraventricular tachycardias. Finally iCEB was assessed in carriers of a long QT syndrome (LQTS, N = 70) or Brugada syndrome (BrS, N = 57) mutation and compared them with genotype negative family members (N = 65).
resultsThe correlation between QT interval and ERP was established (Pearson R(2) = 0.25) which suggests that iCEB≈ERPxCV≈QT/QRS. Sotalol administration increased iCEB (+ 0.23; P = 0.01), while it decreased with the administration of flecainide (-0.21, P = 0.03). In the LQTS group iCEB was increased (5.22 ± 0.93, P < 0.0001) compared to genotype negative family members (4.24 ± 0.5), while it was decreased in the BrS group (3.52 ± 0.43, P < 0.0001).
conclusionsOur data suggest that iCEB (QT/QRS) is a simple but effective ECG surrogate of cardiac wavelength. iCEB is increased in situations that predispose to TdP and is decreased in situations that predispose to non-TdP mediated VT/VF. Therefore, iCEB might serve as a noninvasive and readily measurable marker to detect increased arrhythmic risk.
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