ArticleMolecular endocrinology (Baltimore, Md.)2015
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.
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Article in Molecular endocrinology (Baltimore, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
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21 citing papers in PubMed, 32 citations in OpenAlex.
- Genetic Determinants of Treatment-Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia.Clinical pharmacology and therapeutics · 2026Article
- Analysis of Transcriptome and Differentially Expressed Genes in Chicken Primordial Germ Cells.Animals : an open access journal from MDPI · 2026Article
- De novo transcriptome assembly and gene expression analysis of Cnidium officinale under high-temperature conditions.BMC genomics · 2025Article
- Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer.Cell reports · 2025Article
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- 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.medRxiv : the preprint server for health sciences · 2024Article
- N-terminal domain of androgen receptor is a major therapeutic barrier and potential pharmacological target for treating castration resistant prostate cancer: a comprehensive review.Frontiers in pharmacology · 2024Review
- HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers.Nucleic acids research · 2023Article
- SH3YL1 Protein Predicts Renal Outcomes in Patients with Type 2 Diabetes.Life (Basel, Switzerland) · 2023Article
- A chemical probe for BAG1 targets androgen receptor-positive prostate cancer through oxidative stress signaling pathway.iScience · 2022Article
- Article
- Analyzing the Androgen Receptor Interactome in Prostate Cancer: Implications for Therapeutic Intervention.Cells · 2022Review
- The evolution and polymorphism of mono-amino acid repeats in androgen receptor and their regulatory role in health and disease.Frontiers in medicine · 2022Review
- Genome-Wide Methylation Mapping Using Nanopore Sequencing Technology Identifies Novel Tumor Suppressor Genes in Hepatocellular Carcinoma.International journal of molecular sciences · 2021Article
- Identification of transcription factor co-regulators that drive prostate cancer progression.Scientific reports · 2020Article
- Male-specific association of the 2p25 region with suicide attempt in bipolar disorder.Journal of psychiatric research · 2020Article
- Single Cell Gene Co-Expression Network Reveals FECH/CROT Signature as a Prognostic Marker.Cells · 2019Article
- Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line.Journal of translational medicine · 2019Article
- GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.Endocrine-related cancer · 2018Article
- ELF5-Mediated AR Activation Regulates Prostate Cancer Progression.Scientific reports · 2017Article
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Authors and funding
11 authors at 7 institutions in 3 countries.
Alicia M BlessingCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Sathya GanesanCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Kimal RajapaksheCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Ying Ying SungCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Lakshmi Reddy BolluCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Yan ShiCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Edwin CheungCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Cristian CoarfaCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Jeffrey T ChangCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Donald P McDonnellCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
Daniel E FrigoCenter for Nuclear Receptors and Cell Signaling (A.M.B., Y.S., D.E.F.), Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204; R&D Compliance (S.G.), Grifols Therapeutics Inc, Research Triangle Park, North Carolina 27709; Department of Pharmacology and Cancer Biology (S.G., D.P.M.), Duke University School of Medicine, Durham, North Carolina 27710; Department of Molecular and Cellular Biology (K.R., C.C.), Baylor College of Medicine, Houston, Texas 77030; Cancer Biology and Pharmacology (Y.Y.S., E.C.), Genome Institute of Singapore, A*STAR, Singapore 138672; Department of Clinical Cancer Prevention (L.R.B.), The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Faculty of Health Sciences (E.C.), University of Macau, Taipa, Macau, China, 9999078; Department of Integrative Biology and Pharmacology (J.T.C.), School of Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030; and Genomic Medicine Program (D.E.F.), The Houston Methodist Research Institute, Houston, Texas 77030.
University of Houston · USBaylor College of Medicine · USDuke University · USGenome Institute of Singapore · SGThe University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · USUniversity of Macau · MO
Funding
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4MMolecular Determinants of Androgen Receptor PharmacologyR01CA139818 · NCI · DUKE UNIVERSITY · PI MCDONNELL, DONALD P · 2009 to 2013
$1.7MNonclassical signaling of the androgen receptor polyproline domainK01DK084205 · NIDDK · UNIVERSITY OF HOUSTON · PI FRIGO, DANIEL EDWARD · 2009 to 2011
$383kNCATS NIH HHS TL1TR000371NCATS NIH HHS UL1 TR000371NCI NIH HHS R01 CA139818NCI NIH HHS R01CA139818NIDDK NIH HHS K01 DK084205NIDDK NIH HHS K01DK084205
Abstract
Nuclear receptor (NR)-mediated transcriptional activity is a dynamic process that is regulated by the binding of ligands that induce distinct conformational changes in the NR. These structural alterations lead to the differential recruitment of coregulators (coactivators or corepressors) that control the expression of NR-regulated genes. Here, we show that a stretch of proline residues located within the N-terminus of androgen receptor (AR) is a bona fide coregulator binding surface, the disruption of which reduces the androgen-dependent proliferation and migration of prostate cancer (PCa) cells. Using T7 phage display, we identified a novel AR-interacting protein, Src homology 3 (SH3)-domain containing, Ysc84-like 1 (SH3YL1), whose interaction with the receptor is dependent upon this polyproline domain. As with mutations within the AR polyproline domain, knockdown of SH3YL1 attenuated androgen-mediated cell growth and migration. RNA expression analysis revealed that SH3YL1 was required for the induction of a subset of AR-modulated genes. Notable was the observation that ubinuclein 1 (UBN1), a key member of a histone H3.3 chaperone complex, was a transcriptional target of the AR/SH3YL1 complex, correlated with aggressive PCa in patients, and was necessary for the maximal androgen-mediated proliferation and migration of PCa cells. Collectively, these data highlight the importance of an amino-terminal activation domain, its associated coregulator, and downstream transcriptional targets in regulating cellular processes of pathological importance in PCa.
Indexed as
AndrogensCarrier ProteinsCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleMembrane ProteinsModels, BiologicalNuclear ProteinsPeptidesPrognosisProtein BindingProtein Structure, TertiaryAndrogensAR protein, humanCarrier ProteinsMembrane ProteinsNuclear ProteinsPeptidespolyprolineReceptors, AndrogenSH3YL1 protein, humanTranscription FactorsUBN1 protein, human
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