ArticleOncotarget2015
Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- The long noncoding RNAFrontiers in immunology · 2026Article
- Modeling ncRNA Synergistic Regulation in Cancer.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Surveying lncRNA-lncRNA cooperations reveals dominant effect on tumor immunity cross cancers.Communications biology · 2022Article
- Identification of novel key regulatory lncRNAs in gastric adenocarcinoma.BMC genomics · 2022Review
- Non-Coding RNAs Are Brokers in Breast Cancer Interactome Networks and Add Discrimination Power between Subtypes.Journal of clinical medicine · 2022Article
- LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p.Cell death & disease · 2021Article
- Emerging role of non-coding RNA in health and disease.Metabolic brain disease · 2021Review
- Distinct Extracellular RNA Profiles in Different Plasma Components.Frontiers in genetics · 2021Article
- lncRNA SNHG16 Exerts Oncogenic Functions in Promoting Proliferation of Glioma Through Suppressing p21.Pathology oncology research : POR · 2020Article
- LNRLMI: Linear neighbour representation for predicting lncRNA-miRNA interactions.Journal of cellular and molecular medicine · 2020Article
- Non-Coding RNAs and their Integrated Networks.Journal of integrative bioinformatics · 2019Review
- A novel risk score system for assessment of ovarian cancer based on co-expression network analysis and expression level of five lncRNAs.BMC medical genetics · 2019Article
- Article
- Are Long Noncoding RNAs New Potential Biomarkers in Gastrointestinal Stromal Tumors (GISTs)? The Role of H19 and MALAT1.Journal of oncology · 2019Article
- Novel link prediction for large-scale miRNA-lncRNA interaction network in a bipartite graph.BMC medical genomics · 2018Article
- Constructing prediction models from expression profiles for large scale lncRNA-miRNA interaction profiling.Bioinformatics (Oxford, England) · 2018Article
- The emergence of long non-coding RNAs in hepatocellular carcinoma: an update.Journal of Cancer · 2018Review
- Quantitative assessment of lncRNAOncotarget · 2017Article
- Global Prioritizing Disease Candidate lncRNAs via a Multi-level Composite Network.Scientific reports · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (lncRNAs) play key roles in diverse biological processes. Moreover, the development and progression of cancer often involves the combined actions of several lncRNAs. Here we propose a multi-step method for constructing lncRNA-lncRNA functional synergistic networks (LFSNs) through co-regulation of functional modules having three features: common coexpressed genes of lncRNA pairs, enrichment in the same functional category and close proximity within protein interaction networks. Applied to three cancers, we constructed cancer-specific LFSNs and found that they exhibit a scale free and modular architecture. In addition, cancer-associated lncRNAs tend to be hubs and are enriched within modules. Although there is little synergistic pairing of lncRNAs across cancers, lncRNA pairs involved in the same cancer hallmarks by regulating same or different biological processes. Finally, we identify prognostic biomarkers within cancer lncRNA expression datasets using modules derived from LFSNs. In summary, this proof-of-principle study indicates synergistic lncRNA pairs can be identified through integrative analysis of genome-wide expression data sets and functional information.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.