Trial reportAmerican journal of health promotion : AJHP2016
The Effects of Tai Chi on Cardiovascular Risk in Women.
Trial report in American journal of health promotion : AJHP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 7 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Comparative efficacy of traditional Chinese medicine-based non-pharmacological therapies for managing cancer-related fatigue in lung cancer patients: a systematic review and network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- A systematic review and meta-analysis of the mechanism of action of Tai Chi on cardiovascular disease: evidence map of aerobic and mind-body exercise pathways.Scientific reports · 2026Pooled it
- Effectiveness of mindfulness-based interventions on inflammaging: a systematic review and meta-analysis.Biogerontology · 2025Pooled it
- Effects of mind-body exercise on physical ability, mental health and quality of life in stroke patients: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Religiosity/Spirituality and Physiological Markers of Health.Journal of religion and health · 2020Pooled it
- Efficacy of Tai Chi and qigong for the prevention of stroke and stroke risk factors: A systematic review with meta-analysis.Medicine · 2017Pooled it
- Health benefits of tai chi: What is the evidence?Canadian family physician Medecin de famille canadien · 2016Pooled it
- Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention.International journal of environmental research and public health · 2021Trial
- Treatment Fidelity in Mind-Body Interventions.Journal of holistic nursing : official journal of the American Holistic Nurses' Association · 2019Trial
- The Effects of Mind-Body Exercises on Chronic Spinal Pain Outcomes: A Synthesis Based on 72 Meta-Analyses.International journal of environmental research and public health · 2022Review
- The Positive Role of Tai Chi in Responding to the COVID-19 Pandemic.International journal of environmental research and public health · 2021Article
- Susceptibility of Women to Cardiovascular Disease and the Prevention Potential of Mind-Body Intervention by Changes in Neural Circuits and Cardiovascular Physiology.Biomolecules · 2021Review
- The Effects of Tai Chi and Qigong on Immune Responses: A Systematic Review and Meta-Analysis.Medicines (Basel, Switzerland) · 2020Review
- Effects ofJournal of alternative and complementary medicine (New York, N.Y.) · 2019Review
- Review
- Psychometric Evaluation of the Patient-Reported Outcomes Measurement Information System Fatigue-Short Form Across Diverse Populations.Nursing researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study examined the effects of tai chi (TC) on biobehavioral factors associated with cardiovascular disease (CVD) risk in women.
designA randomized trial used a wait-list control group, pretest-posttest design. Data were collected immediately before, immediately after, and 2 months following the intervention.
settingThe study was community based in central Virginia. SUBJECTS: Women aged 35 to 50 years at increased risk for CVD.
interventionThe 8-week intervention built on prior work and was designed to impact biobehavioral factors associated with CVD risk in women. MEASURES: Biological measures included fasting glucose, insulin, and lipids as well as C-reactive protein and cytokines. Behavioral measures included fatigue, perceived stress, depressive symptoms, social support, mindfulness, self-compassion, and spiritual thoughts and behaviors. ANALYSIS: A mixed effects linear model was used to test for differences between groups across time.
resultsIn 63 women, TC was shown to decrease fatigue (∂ [difference in group means] = 9.38, p = .001) and granulocyte colony stimulating factor (∂ = 12.61, p = .052). Consistent with the study model and intervention design, significant changes observed 2 months post intervention indicated that TC may help down-regulate proinflammatory cytokines associated with underlying CVD risk, including interferon gamma (∂ = 149.90, p = .002), tumor necrosis factor (∂ = 16.78, p = .002), interleukin (IL) 8 (∂ = 6.47, p = .026), and IL-4 (∂ = 2.13, p = .001), and may increase mindfulness (∂ = .54, p = .021), spiritual thoughts and behaviors (∂ = 8.30, p = .009), and self-compassion (∂ = .44, p = .045).
conclusionThis study contributes important insights into the potential benefits and mechanisms of TC and, with further research, may ultimately lead to effective strategies for reducing CVD risk in women earlier in the CVD trajectory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.